[HTML][HTML] Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities
X Xu, B Sun, C Zhao - Neurobiology of Disease, 2023 - Elsevier
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …
of the PARP superfamily, with its primary function being the facilitation of DNA damage …
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future
ML Hu, YR Pan, YY Yong, Y Liu, L Yu, DL Qin… - Ageing research …, 2023 - Elsevier
Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a first responder that recognizes DNA
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …
Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin‐evoked peripheral neuropathy
A Areti, P Komirishetty, M Akuthota… - Journal of pineal …, 2017 - Wiley Online Library
Oxaliplatin, an organoplatinum compound, is used in the treatment of colorectal cancer, but
its clinical use can be limited due to the development of peripheral neuropathy. Whilst …
its clinical use can be limited due to the development of peripheral neuropathy. Whilst …
Probucol attenuates NF-κB/NLRP3 signalling and augments Nrf-2 mediated antioxidant defence in nerve injury induced neuropathic pain
K Derangula, M Javalgekar, V Kumar Arruri… - International …, 2022 - Elsevier
Neuroinflammation is one of the most significant pathological drivers following nerve injury
which along with immune cell activation, oxidative stress and other associated molecular …
which along with immune cell activation, oxidative stress and other associated molecular …
Poly (ADP-Ribose) polymerase-1 (PARP-1) overactivity plays a pathogenic role in bile acids-induced nephrotoxicity in cholestatic rats
A Siavashpour, B Khalvati, N Azarpira, H Mohammadi… - Toxicology letters, 2020 - Elsevier
Cholestatic liver disease is a clinical complication with a wide range of etiologies. The liver
is the primary organ influenced by cholestasis. Other organs, rather than the liver (eg …
is the primary organ influenced by cholestasis. Other organs, rather than the liver (eg …
[HTML][HTML] Isoquercitrin promotes peripheral nerve regeneration through inhibiting oxidative stress following sciatic crush injury in mice
J Qiu, X Yang, L Wang, Q Zhang, W Ma… - Annals of …, 2019 - ncbi.nlm.nih.gov
Background Oxidative stress has been recognized to play a crucial role in the pathogenesis
of peripheral nerve injury. Isoquercitrin (quercetin-3-glucoside) is a flavonoid that exhibited …
of peripheral nerve injury. Isoquercitrin (quercetin-3-glucoside) is a flavonoid that exhibited …
PARP-1-regulated TNF-α expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats
Y Gao, L Bai, W Zhou, Y Yang, J Zhang, L Li… - Brain, Behavior, and …, 2020 - Elsevier
Emerging evidence has implicated poly-(ADP-ribose) polymerase 1 (PARP-1), a
transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the …
transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the …
Carvacrol abates NLRP3 inflammasome activation by augmenting Keap1/Nrf-2/p62 directed autophagy and mitochondrial quality control in neuropathic pain
VK Arruri, C Gundu, AK Kalvala… - Nutritional …, 2022 - Taylor & Francis
Objectives: We aimed to evaluate the effect of carvacrol (CRC), a phenolic monoterpene
with high nutritional value on NLRP3 activation against chronic constriction injury (CCI) of …
with high nutritional value on NLRP3 activation against chronic constriction injury (CCI) of …
[HTML][HTML] Therapeutic applications of PARP inhibitors in ovarian cancer
H Xie, W Wang, B Xia, W Jin, G Lou - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Ovarian cancer is the most lethal gynecologic malignancy with a high recurrence rate. Poly
(ADP-ribose) polymerase inhibitors (PARPi) are one of the most active new therapies for …
(ADP-ribose) polymerase inhibitors (PARPi) are one of the most active new therapies for …
Rosmarinic acid mitigates mitochondrial dysfunction and spinal glial activation in oxaliplatin-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting complication which
develops as a consequence of treatment with chemotherapeutic agents like oxaliplatin and …
develops as a consequence of treatment with chemotherapeutic agents like oxaliplatin and …