Factors Affecting Polyphenol Biosynthesis in Wild and Field Grown St. John's Wort (Hypericum perforatum L. Hypericaceae/Guttiferae)

R Bruni, G Sacchetti - Molecules, 2009 - mdpi.com
The increasing diffusion of herbal products is posing new questions: why are products so
often different in their composition and efficacy? Which approach is more suitable to …

Hypericum sp.: essential oil composition and biological activities

AP Guedes, G Franklin, M Fernandes-Ferreira - Phytochemistry reviews, 2012 - Springer
Phytochemical composition of Hypericum genus has been investigated for many years. In
the recent past, studies on the essential oils (EO) of this genus have been progressing and …

Xanthone biosynthesis in Hypericum perforatum cells provides antioxidant and antimicrobial protection upon biotic stress

G Franklin, LFR Conceição, E Kombrink, ACP Dias - Phytochemistry, 2009 - Elsevier
Xanthone production in Hypericum perforatum (HP) suspension cultures in response to
elicitation by Agrobacterium tumefaciens co-cultivation has been studied. RNA blot analyses …

Convergent gene clusters underpin hyperforin biosynthesis in St John's wort

S Wu, AL Malaco Morotti, S Wang, Y Wang… - New …, 2022 - Wiley Online Library
The meroterpenoid hyperforin is responsible for the antidepressant activity of St John's wort
extracts, but the genes controlling its biosynthesis are unknown. Using genome mining and …

Hairy roots of Hypericum perforatum L.: a promising system for xanthone production

O Tusevski, J Stanoeva, M Stefova… - Open Life …, 2013 - degruyter.com
Hypericum perforatum L. is a common perennial plant with a reputed medicinal value.
Investigations have been made to develop an efficient protocol for the identification and …

Phenolic Profile of Dark‐Grown and Photoperiod‐Exposed Hypericum perforatum L. Hairy Root Cultures

O Tusevski, J Petreska Stanoeva… - The Scientific World …, 2013 - Wiley Online Library
Hypericum perforatum L. is a medicinal plant considered as an important natural source of
secondary metabolites with a wide range of pharmacological attributes. Hairy roots (HR) …

Sonication, Vacuum Infiltration and Thiol Compounds Enhance the Agrobacterium-Mediated Transformation Frequency of Withania somnifera (L.) Dunal

G Sivanandhan, G Kapil Dev, J Theboral, N Selvaraj… - PLoS …, 2015 - journals.plos.org
In the present study, we have established a stable transformation protocol via Agrobacterium
tumafacines for the pharmaceutically important Withania somnifera. Six day-old nodal …

Efficient genetic transformation of Jatropha curcas L. by microprojectile bombardment using embryo axes

M Joshi, A Mishra, B Jha - Industrial Crops and Products, 2011 - Elsevier
An efficient and reproducible protocol was established for genetic transformation in Jatropha
curcas through microprojectile bombardment. Decotyledonated embryos were from mature …

Chlorogenic acid participates in the regulation of shoot, root and root hair development in Hypericum perforatum

G Franklin, ACP Dias - Plant Physiology and Biochemistry, 2011 - Elsevier
Chlorogenic acid (CGA), a product of the phenylpropanoid pathway, is one of the most
widespread soluble phenolic compounds in the plant kingdom. Although CGA is known to …

A Perspective on Hypericum perforatum Genetic Transformation

W Hou, P Shakya, G Franklin - Frontiers in Plant Science, 2016 - frontiersin.org
Hypericum perforatum (St John's wort) is a reservoir of diverse classes of biologically active
and high value secondary metabolites, which captured the interest of both researchers and …