Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Abstract Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical
regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various …

Cancer cells have a very different metabolism from that of normal cells from which they are
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that lacks
targeted therapy options, and patients diagnosed with TNBC have poorer outcomes than …

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …