Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

The nematode Caenorhabditis elegans is a research model organism particularly suited to
the mechanistic understanding of synapse genesis in the nervous system. Armed with …

C. elegans develops through four larval stages that are rhythmically terminated by molts, that
is, the synthesis and shedding of a cuticular exoskeleton. Each larval cycle involves rhythmic …

Membrane-bound transcription factors (MTFs) are transcription factors (TFs) that are
anchored in membranes in a dormant state. Activated by external or internal stimuli, MTFs …

Myelin sheath formed by oligodendrocytes (OLs) is essential for the rapid propagation of
action potentials in the vertebrate CNS. Myelin regulatory factor (MYRF) is one of the critical …

Precise developmental timing control is essential for organism formation and function, but its
mechanisms are unclear. In C. elegans, the microRNA lin-4 plays a critical role in …

Myelin Regulatory Factor (MYRF) is a transcription factor that has previously been
associated with the control of the expression of myelin‐related genes. However, it is highly …

Circuit refinement involves the formation of new presynaptic boutons as others are
dismantled. Nascent presynaptic sites can incorporate material from recently eliminated …

During development, animals can maintain behavioral output even as underlying circuitry
structurally remodels. After hatching, C. elegans undergoes substantial motor neuron …

High hyperopia is a common and severe form of refractive error. Genetic factors play
important roles in the development of high hyperopia but the exact gene responsible for this …