Triple negative breast cancer: A thorough review of biomarkers

JL da Silva, NCC Nunes, P Izetti… - Critical reviews in …, 2020 - Elsevier
Triple-negative breast cancer (TNBC) is defined as a type of breast cancer with lack of
expression of estrogen receptor (ER), progesterone receptor (PR) and HER2 protein. The …

Novel diagnostic biomarkers in colorectal cancer

AL Zygulska, P Pierzchalski - International journal of molecular sciences, 2022 - mdpi.com
Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Epigenetics and allergy: from basic mechanisms to clinical applications

DP Potaczek, H Harb, S Michel, BA Alhamwe… - …, 2017 - Taylor & Francis
Allergic diseases are on the rise in the Western world and well-known allergy-protecting and-
driving factors such as microbial and dietary exposure, pollution and smoking mediate their …

Epigenetics and human obesity

SJ Van Dijk, PL Molloy, H Varinli, JL Morrison… - International journal of …, 2015 - nature.com
Background: Recent technological advances in epigenome profiling have led to an
increasing number of studies investigating the role of the epigenome in obesity. There is …

Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification

S Rauschert, K Raubenheimer, PE Melton… - Clinical epigenetics, 2020 - Springer
Background Machine learning is a sub-field of artificial intelligence, which utilises large data
sets to make predictions for future events. Although most algorithms used in machine …

DNA methylation biomarkers: cancer and beyond

T Mikeska, JM Craig - Genes, 2014 - mdpi.com
Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

T Dayeh, T Tuomi, P Almgren, A Perfilyev… - Epigenetics, 2016 - Taylor & Francis
Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental
for prevention of the disease. Consequently, it is essential to search for new biomarkers that …

Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years …

DD Buchanan, YY Tan, MD Walsh… - Journal of Clinical …, 2014 - ascopubs.org
Purpose Clinicopathologic data from a population-based endometrial cancer cohort,
unselected for age or family history, were analyzed to determine the optimal scheme for …

Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer

JMK Ng, J Yu - International journal of molecular sciences, 2015 - mdpi.com
Colorectal cancer (CRC) is a common malignancy and the fourth leading cause of cancer
deaths worldwide. It results from the accumulation of multiple genetic and epigenetic …