Research during the last decade has significantly advanced our understanding of the
molecular mechanisms at the interface between the nervous system and the immune …

Neural reflex circuits regulate cytokine release to prevent potentially damaging inflammation
and maintain homeostasis. In the inflammatory reflex, sensory input elicited by infection or …

Objective: Lethal sepsis occurs when an excessive inflammatory response evolves that
cannot be controlled by physiologic anti-inflammatory mechanisms, such as the recently …

The α7-nicotinic acetylcholine receptor (α7nAChR) is a key protein in the cholinergic anti-
inflammatory pathway (CAP) that links the nervous and immune systems. Initially, the …

Advances in understanding the regulatory functions of the nervous system have revealed
neural cholinergic signaling as a key regulator of cytokine responses and inflammation …

Improved understanding of neuroimmune communication and the neural regulation of
immunity and inflammation has recently led to proposing the concept of the “neuroimmune …

BACKGROUND It is hypothesized that chronic increase of availability of acetylcholine,
resulting from the effect of antiacetylcholinesterases, may prevent autonomic imbalance and …

Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the
function of the cholinergic neuromuscular junction. Recent studies have shown that …

Background Mechanical ventilation (MV) induces an inflammatory response that can lead to
lung injury. The vagus nerve can limit the inflammatory response through the cholinergic anti …

Rationale: This study was performed to gain insights into novel therapeutic approaches for
the treatment of autoimmune myocarditis. Objective: Chemical stimulation of the efferent arm …