The ability to produce plethora of secondary metabolites and enzymes for pharmaceutical,
agricultural and biotechnological applications make actinobacteria one of the most explored …

Covering: up to 2018 α-Ketoglutarate (αKG, also known as 2-oxoglutarate)-dependent
mononuclear non-haem iron (αKG-NHFe) enzymes catalyze a wide range of biochemical …

Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

Tuberculosis is the leading infectious disease responsible for an estimated one and a half
million human deaths each year around the globe. HIV-TB coinfection and rapid increase in …

Actinomycetes are regarded as important sources for the generation of various bioactive
secondary metabolites with rich chemical and bioactive diversities. Amycolatopsis falls …

l-threo-p-methylsulfonylphenylserine (compound 1b) is the main intermediate of florfenicol,
and its efficient synthesis has been the subject of current research. Herein, Burkholderia …

Bacterial extracellular vesicles (BEVs) are nanosized lipid bilayers generated from
membranes that are filled with components derived from bacteria. BEVs are important for the …

Pyridoxal 5′‐phosphate (PLP) is an organic cofactor employed by~ 4% of enzymes. The
structure of the PLP cofactor allows for the stabilization of carbanions through resonance. A …

Tuberculosis is an ever evolving infectious disease that still claims about 1.8 million human
lives each year around the globe. Although modern chemotherapy has played a pivotal role …

The biosynthesis of the lincosamide antibiotics lincomycin A and celesticetin involves the
pyridoxal-5′-phosphate (PLP)-dependent enzymes LmbF and CcbF, which are responsible …