Neutrophilic inflammation has a key role in the pathophysiology of multiple chronic lung
diseases. The formation of neutrophil extracellular traps (NETs) has emerged as a key …

Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are
limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the …

Severe coronavirus disease 2019 (COVID-19) can result in pneumonia and acute
respiratory failure. Accumulation of mucus in the airways is a hallmark of the disease and …

The respiratory mucus, a viscoelastic gel, effectuates a primary line of the airway defense
when operated by the mucociliary clearance. In chronic respiratory diseases (CRDs), such …

The identification of markers of inflammatory activity at the early stages of pulmonary
diseases which share common characteristics that prevent their clear differentiation is of …

Rationale Pulmonary exacerbations are clinically impactful events that accelerate cystic
fibrosis (CF) lung disease progression. The pathophysiological mechanisms underlying an …

Cystic fibrosis (CF) is a hereditary disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene, triggering dysfunction of the anion channel in several …

Background Proteomics can reveal molecular pathways of disease and provide translational
perspectives to inform clinical decision making. Although several studies have previously …

A scoping review methodological framework formed the basis of this review. A search of two
electronic databases captured relevant literature published from 2013. 1184 articles were …

Microorganisms proteotyping by tandem mass spectrometry has been recently shown as a
powerful methodology to identify the wide-range taxonomy and biomass of microbiota …