In vitro reconstitution assays using purified actin have greatly improved our understanding of
cytoskeletal dynamics and their regulation by actin-binding proteins. However, early …

Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of
surface receptors through which they regulate a broad spectrum of biological processes …

Extracellular vesicles (EVs) are released from nearly all mammalian cells and different EV
populations have been described. Microvesicles represent large EVs (LEVs) released from …

Abstract Actin beta-like 2 (ACTBL2) was recently identified as a new mediator of migration in
ovarian cancer cells. Yet, its impact on tumor-infiltrating and thus migrating leukocytes (TILs) …

Thymosin β4 (Tβ4), a multifunctional 44-amino acid polypeptide and a member of actin-
binding proteins (ABPs), plays an important role in developmental processes and wound …

We have recently found that β-actin-like protein 2 (actbl2) forms complexes with gelsolin in
human melanoma cells and can polymerize. Phylogenetic and bioinformatic analyses …

Early diagnosis of colorectal cancer (CRC) can be of value for increasing the survival rate of
patients. Recently, proteomic strategies to identify markers for the diagnosis of cancer at an …

Intermediate filaments play significant roles in governing cell stiffness and invasive ability.
Nestin is a type VI intermediate filament protein that is highly expressed in several high …

Aging-associated loss of skeletal muscle mass and force increases the risk of falls, impairs
mobility, and leads to a reduced quality of life. High-intensity interval training (HIIT) is …

The understanding of melanoma malignancy mechanisms is essential for patient survival,
because melanoma is responsible for ca. 75% of deaths related to skin cancers. Enhanced …