Structure, function and disease relevance of Omega-class glutathione transferases

PG Board, D Menon - Archives of toxicology, 2016 - Springer
The Omega-class cytosolic glutathione transferases (GSTs) have distinct structural and
functional attributes that allow them to perform novel roles unrelated to the functions of other …

[HTML][HTML] Valproate decreases vitamin D levels in pediatric patients with epilepsy

Z Xu, X Jing, G Li, J Sun, H Guo, Y Hu, F Sun, X Wen… - Seizure, 2019 - Elsevier
Abstract Purpose To compare Vitamin D (Vit D) levels in children with epilepsy on valproate
monotherapy with healthy controls. Methods A meta-analysis performed on articles identified …

Correlation between heavy metal exposure and GSTM1 polymorphism in Iranian multiple sclerosis patients

M Aliomrani, MA Sahraian, H Shirkhanloo… - Neurological …, 2017 - Springer
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory disease of the central
nervous system. Various exposures to heavy metals can lead to toxicity and oxidative stress …

Somatic mutations and Alzheimer's disease

J Downey, JCK Lam, VOK Li… - Journal of Alzheimer's …, 2022 - content.iospress.com
Alzheimer's disease (AD) represents a global health challenge, with an estimated 55 million
people suffering from the non-curable disease across the world. While amyloid-plaques and …

Studies on diagnostic biomarkers and therapeutic mechanism of Alzheimer's disease through metabolomics and hippocampal proteomics

W Lin, J Zhang, Y Liu, R Wu, H Yang, X Hu… - European Journal of …, 2017 - Elsevier
Alzheimer's disease (AD) is the main cause of dementia, but precise diagnosis and
treatment are not sufficient so far. The purpose of this study is to develop biomarkers and …

Dynamic changes and prognostic value of glutathione S-transferase alpha in mild cognitive impairment and Alzheimer's disease

Y Tang, N Li, L Dai, X Wang, X Lai - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Objectives Glutathione S-transferase alpha (GSTα) is an important antioxidant enzyme
closely associated with the onset and progression of neurodegenerative diseases. The …

Genetic dissection of glutathione S-transferase omega-1: identification of novel downstream targets and Alzheimer's disease pathways

Y Jia, MD Gao, YF Liu, L Lu, G Chen… - Neural Regeneration …, 2022 - journals.lww.com
Alzheimer's disease (AD) is affected by genetic factors. Polymorphisms in the glutathione S-
transferase omega-1 (Gsto1) gene have been shown by genetic correlation analyses …

[HTML][HTML] Biomarker discovery process at binomial decision point (2BDP): Analytical pipeline to construct biomarker panel

N Chakraborty, A Lawrence, R Campbell… - Computational and …, 2023 - Elsevier
A clinical incident is typically manifested by several molecular events; therefore, it seems
logical that a successful diagnosis, prognosis, or stratification of a clinical landmark require …

Macrophage migration inhibitory factor is a valid drug target at the intersection of herpes simplex virus 1 replication and Alzheimer's disease-relevant cellular …

A Müller-Schiffmann, F Torres, A Kitaygorodskyy… - BioRxiv, 2021 - biorxiv.org
Herpes virus infections are endemic and ubiquitous. While only rarely leading to overt
encephalitis, subchronic or latent infections have been associated to a variety of conditions …

Deep proteome analysis of plasma reveals novel biomarkers of mild cognitive impairment and Alzheimer's disease: A longitudinal study

G Kaur, A Poljak, P Sachdev - bioRxiv, 2022 - biorxiv.org
Ageing is the primary risk factor for AD; however, there is a poor understanding of the
biological mechanisms by which the ageing process contributes to the development of AD in …