Mitochondria as a target of environmental toxicants

JN Meyer, MCK Leung, JP Rooney… - toxicological …, 2013 - academic.oup.com
Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …

[HTML][HTML] How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models

MW van Gisbergen, AM Voets, MHW Starmans… - … Research/Reviews in …, 2015 - Elsevier
Several mutations in nuclear genes encoding for mitochondrial components have been
associated with an increased cancer risk or are even causative, eg succinate …

[HTML][HTML] Mitochondrial dysfunction in metabolic disorders induced by per-and polyfluoroalkyl substance mixtures in zebrafish larvae

Y Liu, S Liu, J Huang, Y Liu, Q Wang, J Chen… - Environment …, 2023 - Elsevier
Several per-and polyfluoroalkyl substances (PFAS) have been linked to metabolic disorders
in organisms. However, few studies have considered their combined effects, which would be …

Cone photoreceptors transfer damaged mitochondria to Müller glia

RA Hutto, KM Rutter, MM Giarmarco, ED Parker… - Cell reports, 2023 - cell.com
Mitochondria are vital organelles that require sophisticated homeostatic mechanisms for
maintenance. Intercellular transfer of damaged mitochondria is a recently identified strategy …

Function over form: modeling groups of inherited neurological conditions in zebrafish

RA Kozol, AJ Abrams, DM James, E Buglo… - Frontiers in molecular …, 2016 - frontiersin.org
Zebrafish are a unique cell to behavior model for studying the basic biology of human
inherited neurological conditions. Conserved vertebrate genetics and optical transparency …

Fatty acid oxidation in zebrafish adipose tissue is promoted by 1α, 25 (OH) 2D3

X Peng, G Shang, W Wang, X Chen, Q Lou, G Zhai… - Cell reports, 2017 - cell.com
Summary 1α, 25 (OH) 2 D 3 (vitamin D 3) is crucial for mineral homeostasis in mammals, but
the precise effects of 1α, 25 (OH) 2 D 3 in adipose tissue remain to be clarified in vivo. The …

The control of mtDNA replication during differentiation and development

JS John - Biochimica et Biophysica Acta (BBA)-General Subjects, 2014 - Elsevier
Abstract Background Mitochondrial DNA (mtDNA) is important for energy production as it
encodes some of the key genes of electron transfer chain, where the majority of cellular …

Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism

L Qian, J Zhang, X Chen, S Qi, P Wu, C Wang… - Environmental …, 2019 - Elsevier
Boscalid as one of the most widely used succinate dehydrogenase inhibitor (SDHI)
fungicides has been frequently detected in both freshwater and estuarine environments. Its …

[HTML][HTML] Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)

B Ren, T Zhao, Y Li, H Liang, Y Zhao, H Chen… - Ecotoxicology and …, 2021 - Elsevier
Succinate dehydrogenase inhibitor (SDHI) fungicides has been extensively used in
agricultural production, which are not easily degrade in the environment and have various …

Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo (a) pyrene in Danio rerio

JS Kozal, N Jayasundara, A Massarsky, CD Lindberg… - Aquatic Toxicology, 2023 - Elsevier
The potential for polycyclic aromatic hydrocarbons (PAHs) to have adverse effects that
persist across generations is an emerging concern for human and wildlife health. This study …