New and emerging approaches to treat psychiatric disorders

KW Scangos, MW State, AH Miller, JT Baker… - Nature medicine, 2023 - nature.com
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Non-invasive transcranial ultrasound stimulation for neuromodulation

G Darmani, TO Bergmann, KB Pauly, CF Caskey… - Clinical …, 2022 - Elsevier
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …

High-intensity focused ultrasound: a review of mechanisms and clinical applications

VS Bachu, J Kedda, I Suk, JJ Green, B Tyler - Annals of biomedical …, 2021 - Springer
Abstract High Intensity Focused Ultrasound (HIFU) is an emerging and increasingly useful
modality in the treatment of cancer and other diseases. Although traditional use of …

Ultrasound technologies for imaging and modulating neural activity

C Rabut, S Yoo, RC Hurt, Z Jin, H Li, H Guo, B Ling… - Neuron, 2020 - cell.com
Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …

Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans

SN Yaakub, TA White, J Roberts, E Martin… - Nature …, 2023 - nature.com
Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive
technique for focally modulating human brain function. The mechanisms and neurochemical …

Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress

Y Shi, W Wu - BMC medicine, 2023 - Springer
Background Chronic pain conditions impose significant burdens worldwide.
Pharmacological treatments like opioids have limitations. Non-invasive non …

[HTML][HTML] Human Studies of Transcranial Ultrasound neuromodulation: A systematic review of effectiveness and safety

C Sarica, JF Nankoo, A Fomenko, TC Grippe… - Brain stimulation, 2022 - Elsevier
Background Transcranial ultrasound stimulation (TUS) is gaining traction as a safe and non-
invasive technique in human studies. There has been a rapid increase in TUS human …

The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation

J Zhu, Q Xian, X Hou, KF Wong, T Zhu… - Proceedings of the …, 2023 - National Acad Sciences
Transcranial low-intensity ultrasound is a promising neuromodulation modality, with the
advantages of noninvasiveness, deep penetration, and high spatiotemporal accuracy …

Ultrasound as a versatile tool for short-and long-term improvement and monitoring of brain function

DG Blackmore, D Razansky, J Götz - Neuron, 2023 - cell.com
Treating the brain with focused ultrasound (FUS) at low intensities elicits diverse responses
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …

Induction of human motor cortex plasticity by theta burst transcranial ultrasound stimulation

K Zeng, G Darmani, A Fomenko, X Xia… - Annals of …, 2022 - Wiley Online Library
Objective Transcranial ultrasound stimulation (TUS) is a promising noninvasive brain
stimulation technique with advantages of high spatial precision and ability to target deep …