Circular RNA—Is the Circle Perfect?

L Caba, L Florea, C Gug, DC Dimitriu, EV Gorduza - Biomolecules, 2021 - mdpi.com
Circular RNA (circRNA) is a distinct class of non-coding RNA produced, in principle, using a
back-splicing mechanism, conserved during evolution, with increased stability and a tissue …

Colon cancer transcriptome

K Mokhtari, M Peymani, M Rashidi… - Progress in biophysics …, 2023 - Elsevier
Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis

R Ou, S Lu, L Wang, Y Wang, M Lv, T Li, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Background A number of studies have demonstrated that circular RNA (circRNA) plays a
critical role in tumorigenesis and tumor progression. However, the biological effects of most …

m6A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation

W Zeng, JF Zhu, J Guo, GJ Huang, LS Ai, Y Zeng… - Cell death & …, 2022 - nature.com
Colorectal cancer (CRC) is the third most frequently diagnosed cancer with unfavorable
clinical outcomes worldwide. circFNDC3B plays as a tumor suppressor in CRC, however …

Promises and challenges of predictive blood biomarkers for locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

JV Machado Carvalho, V Dutoit, C Corrò, T Koessler - Cells, 2023 - mdpi.com
The treatment of locally advanced rectal cancer (LARC) requires a multimodal approach
combining neoadjuvant radiotherapy or chemoradiotherapy (CRT) and surgery. Predicting …

Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer

G Hu, C Lin, K Gao, M Chen, F Long, B Tian - Molecular Medicine, 2023 - Springer
Background Colorectal cancer (CRC) is the third frequently diagnosed cancer with high
incidence and mortality rate worldwide. Our previous report has demonstrated that …

Role of circular RNA and its delivery strategies to cancer–An overview

SSK Yalamarty, N Filipczak, MM Khan… - Journal of Controlled …, 2023 - Elsevier
With the passage of years and the progress of research on ribonucleic acids, the range of
forms in which these molecules have been observed grows. One of them, discovered …

[HTML][HTML] YAP derived circ-LECRC functions as a “brake signal” to suppress hyperactivation of oncogenic YAP signalling in colorectal cancer

Y An, B Xu, G Yan, N Wang, Z Yang, M Sun - Cancer Letters, 2022 - Elsevier
Accumulating evidence indicates that circular RNAs (circRNAs) play vital roles in
tumorigenesis by modulating gene expression. However, the molecular mechanisms …

Circ_0087862 promotes tumorigenesis and glycolysis in colorectal cancer by sponging miR-296-3p to regulate PGK1 expression

W Xiao, P Li - Pathology-Research and Practice, 2023 - Elsevier
Abstract Background Circular RNAs (circRNAs) exert crucial roles in tumor progression of
multiple cancers, including colorectal cancer (CRC). However, the functions of most …

SUMOylation of methyltransferase‐like 3 facilitates colorectal cancer progression by promoting circ_0000677 in an m6A‐dependent manner

Q Liu, Q Huang, H Liu, FJ He, JH Liu… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Aim Colorectal cancer (CRC) is one of the major health issues in
the world. Circ_0000677 has been shown to be upregulated in CRC with unclarified function …