[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function

KK Kummer, M Zeidler, T Kalpachidou, M Kress - Cytokine, 2021 - Elsevier
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Emerging roles for the immune system in traumatic brain injury

CA McKee, JR Lukens - Frontiers in immunology, 2016 - frontiersin.org
Traumatic brain injury (TBI) affects an ever-growing population of all ages with long-term
consequences on health and cognition. Many of the issues that TBI patients face are thought …

Understanding the neuroinflammatory response following concussion to develop treatment strategies

ZR Patterson, MR Holahan - Frontiers in cellular neuroscience, 2012 - frontiersin.org
Mild traumatic brain injuries (mTBI) have been associated with long-term cognitive deficits
relating to trauma-induced neurodegeneration. These long-term deficits include impaired …

Exercise reshapes the brain: molecular, cellular, and structural changes associated with cognitive improvements

M Augusto-Oliveira, GP Arrifano, CG Leal-Nazaré… - Molecular …, 2023 - Springer
Physical exercise is well known as a non-pharmacological and holistic therapy believed to
prevent and mitigate numerous neurological conditions and alleviate ageing-related …

Interleukin-6 in inflammatory and malignant diseases of the pancreas

M Lesina, SM Wörmann, P Neuhöfer, L Song… - Seminars in …, 2014 - Elsevier
Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened
exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and …

Acute CSF interleukin-6 trajectories after TBI: associations with neuroinflammation, polytrauma, and outcome

RG Kumar, ML Diamond, JA Boles, RP Berger… - Brain, behavior, and …, 2015 - Elsevier
Traumatic brain injury (TBI) results in a significant inflammatory burden that perpetuates the
production of inflammatory mediators and biomarkers. Interleukin-6 (IL-6) is a pro …

Inflammation in traumatic brain injury

TT Postolache, A Wadhawan, A Can… - Journal of …, 2020 - content.iospress.com
There is an increasing evidence that inflammation contributes to clinical and functional
outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing …

[HTML][HTML] Contribution of brain or biological reserve and cognitive or neural reserve to outcome after TBI: A meta-analysis (prior to 2015)

JL Mathias, P Wheaton - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
Brain/biological (BR) and cognitive/neural reserve (CR) have increasingly been used to
explain some of the variability that occurs as a consequence of normal ageing and …

Blunted IL-6 and IL-10 response to maximal aerobic exercise in patients with traumatic brain injury

KL Timmerman, WE Amonette, MM Markofski… - European journal of …, 2015 - Springer
Introduction In healthy individuals, strenuous exercise typically results in a transient increase
in the inflammatory cytokine, interleukin-6 (IL-6). This increase in IL-6 is reported to have …

The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention

B Giunta, D Obregon, R Velisetty, PR Sanberg… - Journal of …, 2012 - Springer
A global health problem, traumatic brain injury (TBI) is especially prevalent in the current era
of ongoing world military conflicts. Its pathological hallmark is one or more primary injury …