Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

In the past few years, many exciting papers reported results based on crystal structure
determination by electron diffraction. The aim of this review is to provide general and …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Bacteria can be programmed to create engineered living materials (ELMs) with self-healing
and evolvable functionalities. However, further development of ELMs is greatly hampered by …

Electron crystallography has a storied history which rivals that of its more established X-ray-
enabled counterpart. Recent advances in data collection and analysis have sparked a …

Conspectus Analytical methods allow for the structure determination of submilligram
quantities of complex secondary metabolites. This has been driven in large part by …

Natural products (NPs) have a long history as sources for drug discovery, more than half of
approved drugs are related to NPs, which also exhibit multifaceted advantages in the clinical …

Advances in genome sequencing and bioinformatics methods have identified a myriad of
biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining …