The incompletely fulfilled promise of embryo transfer in cattle—why aren't pregnancy rates greater and what can we do about it?

PJ Hansen - Journal of Animal Science, 2020 - academic.oup.com
Typically, bovine embryos are transferred into recipient females about day 7 after estrus or
anticipated ovulation, when the embryo has reached the blastocyst stage of development …

Epigenetic developmental mechanisms underlying sex differences in cancer

JB Rubin, T Abou-Antoun, JE Ippolito, L Llaci… - The Journal of Clinical …, 2024 - jci.org
Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, and
gender. The mechanisms by which sex and gender work alone and in combination with …

Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics

A Gabory, TJ Roseboom, T Moore, LG Moore… - Biology of sex …, 2013 - Springer
Sex differences occur in most non-communicable diseases, including metabolic diseases,
hypertension, cardiovascular disease, psychiatric and neurological disorders and cancer. In …

Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology

V Van Hoeck, RG Sturmey, P Bermejo-Alvarez… - PloS one, 2011 - journals.plos.org
Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal
disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment …

Sex determines the expression level of one third of the actively expressed genes in bovine blastocysts

P Bermejo-Alvarez, D Rizos, D Rath… - Proceedings of the …, 2010 - National Acad Sciences
Although genetically identical for autosomal Chrs (Chr), male and female preimplantation
embryos could display sex-specific transcriptional regulation. To illustrate sex-specific …

Survival factors regulating ovarian apoptosis--dependence on follicle differentiation

E Markstrom, EC Svensson, R Shao… - …, 2002 - rep.bioscientifica.com
Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Glucose consumption of single post-compaction human embryos is predictive of embryo sex and live birth outcome

DK Gardner, PL Wale, R Collins, M Lane - Human reproduction, 2011 - academic.oup.com
BACKGROUND The aim of this study was to determine the relationship between nutrient
utilization by the human embryo and its subsequent viability after transfer. METHODS The …

[HTML][HTML] Analysis of metabolism to select viable human embryos for transfer

DK Gardner, PL Wale - Fertility and sterility, 2013 - Elsevier
As we move to reducing the number of embryos transferred in a given IVF cycle, ideally
down to one, there is an ever-increasing need for noninvasive quantitative markers of …

Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle

N Forde, CA Simintiras, R Sturmey, S Mamo, AK Kelly… - PloS one, 2014 - journals.plos.org
In cattle, conceptus-maternal interactions are critical for the establishment and maintenance
of pregnancy. A major component of this early interaction involves the transport of nutrients …

New approaches to embryo selection

M Montag, B Toth, T Strowitzki - Reproductive biomedicine online, 2013 - Elsevier
Embryo selection has been an important topic since the introduction of assisted
reproduction, with embryo morphology being the most obvious criterion. Although …