Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics

S Helaine, BP Conlon, KM Davis, DG Russell - Cell Host & Microbe, 2024 - cell.com
Antibiotic resistance, typically associated with genetic changes within a bacterial population,
is a frequent contributor to antibiotic treatment failures. Antibiotic persistence and tolerance …

Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

MS Zeden, LA Gallagher, E Bueno, AC Nolan… - PLoS …, 2023 - journals.plos.org
Central metabolic pathways control virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …

Daptomycin as an option for lock therapy: A systematic literature review

S Tzalis, P Ioannou, E Billiari, DP Kofteridis… - Future …, 2023 - Taylor & Francis
Aim: To review preclinical and clinical data relevant to daptomycin lock therapy in catheter-
related bloodstream infection (CRBSI). Methods: Systematic review in PubMed, Scopus and …

PBP4 is required for serum-induced cell wall thickening and antibiotic tolerance in Staphylococcus aureus

EVK Ledger, RC Massey - Antimicrobial Agents and …, 2024 - journals.asm.org
The bacterial pathogen Staphylococcus aureus responds to the host environment by
synthesizing a thick peptidoglycan cell wall, which protects the bacterium from membrane …

mSphere of Influence: Targeting bacterial signaling and metabolism to overcome antimicrobial resistance

MS Zeden - Msphere, 2024 - Am Soc Microbiol
ABSTRACT Dr Merve Suzan Zeden works in the field of molecular bacteriology and
antibiotic resistance. In this mSphere of Influence article, she reflects on how three papers …