Anti-islet autoantibodies in type 1 diabetes

E Kawasaki - International Journal of Molecular Sciences, 2023 - mdpi.com
Anti-islet autoantibodies serve as key markers in immune-mediated type 1 diabetes (T1D)
and slowly progressive T1D (SPIDDM), also known as latent autoimmune diabetes in adults …

[HTML][HTML] Stiff-person syndrome and GAD antibody-spectrum disorders: GABAergic neuronal excitability, immunopathogenesis and update on antibody therapies

MC Dalakas - Neurotherapeutics, 2022 - Elsevier
Abstract Although antibodies against Glutamic Acid Decarboxylase (GAD) were originally
associated with Stiff Person Syndrome (SPS), they now denote the “GAD antibody-spectrum …

GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions

P Tsiortou, H Alexopoulos… - Therapeutic advances in …, 2021 - journals.sagepub.com
Antibodies against glutamic acid decarboxylase (GAD), originally linked to stiff person
syndrome (SPS), now denote the “GAD antibody-spectrum disorders”(GAD-SD) that also …

Islet autoantibodies

V Lampasona, D Liberati - Current diabetes reports, 2016 - Springer
Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes
(T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA) …

The neurological syndromes associated with glutamic acid decarboxylase antibodies

JF Baizabal-Carvallo - Journal of autoimmunity, 2019 - Elsevier
A number of neurological syndromes have been described in patients with positive serum
antibodies (Abs) against the enzyme glutamic acid decarboxylase (GAD), the rate limiting …

Biomarkers in autoimmune diseases of the central nervous system

F Zhang, X Gao, J Liu, C Zhang - Frontiers in immunology, 2023 - frontiersin.org
The autoimmune diseases of the central nervous system (CNS) represent individual
heterogeneity with different disease entities. Although clinical and imaging features make it …

Advances in the cellular immunological pathogenesis of type 1 diabetes

M Li, LJ Song, XY Qin - Journal of cellular and molecular …, 2014 - Wiley Online Library
Type 1 diabetes is an autoimmune disease caused by the immune‐mediated destruction of
insulin‐producing pancreatic β cells. In recent years, the incidence of type 1 diabetes …

Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: protean additions to the autoimmune central neuropathies

F Ali, M Rowley, B Jayakrishnan, S Teuber… - Journal of …, 2011 - Elsevier
Stiff Person Syndrome (SPS) is a rare autoimmune neurological disease attributable to
autoantibodies to glutamic acid decarboxylase (anti-GAD) more usually associated with the …

Stiff-person syndrome and related disorders—diagnosis, mechanisms and therapies

MC Dalakas - Nature Reviews Neurology, 2024 - nature.com
Stiff-person syndrome (SPS) is the prototypical and most common autoimmune neuronal
hyperexcitability disorder. It presents with stiffness in the limbs and axial muscles, stiff gait …

Pathogenic and physiological autoantibodies in the central nervous system

M Gold, R Pul, JP Bach, M Stangel… - Immunological …, 2012 - Wiley Online Library
In this article, we review the current knowledge on pathological and physiological
autoantibodies directed toward structures in the central nervous system (CNS) with an …