The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology
YX Tao - Endocrine reviews, 2010 - academic.oup.com
Abstract The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR;
however, its function was unknown. Subsequent studies suggest that the MC4R might be …
however, its function was unknown. Subsequent studies suggest that the MC4R might be …
[HTML][HTML] Neural melanocortin receptors in obesity and related metabolic disorders
C Girardet, AA Butler - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Obesity is a global health issue, as it is associated with increased risk of developing chronic
conditions associated with disorders of metabolism such as type 2 diabetes and …
conditions associated with disorders of metabolism such as type 2 diabetes and …
Divergence of melanocortin pathways in the control of food intake and energy expenditure
N Balthasar, LT Dalgaard, CE Lee, J Yu, H Funahashi… - Cell, 2005 - cell.com
Summary Activation of melanocortin-4-receptors (MC4Rs) reduces body fat stores by
decreasing food intake and increasing energy expenditure. MC4Rs are expressed in …
decreasing food intake and increasing energy expenditure. MC4Rs are expressed in …
Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese …
The melanocortin-4 receptor (MC4R) is well recognized as an important mediator of body
weight homeostasis. Activation of MC4R causes dramatic weight loss in rodent models, and …
weight homeostasis. Activation of MC4R causes dramatic weight loss in rodent models, and …
Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice
S Chen, L Zhao, P Sherchan, Y Ding, J Yu… - Journal of …, 2018 - Springer
Background Neuroinflammation plays an important role in the pathogenesis of intracerebral
hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 …
hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 …
Melanocortin-4 receptor–deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia
LS Tallam, DE Stec, MA Willis, AA da Silva, JE Hall - Hypertension, 2005 - Am Heart Assoc
The purpose of this study was to test whether the melanocortin-4 receptor (MC4R) is critical
in the development of hypertension associated with obesity and its metabolic disorders …
in the development of hypertension associated with obesity and its metabolic disorders …
Distribution and function of melanocortin receptors within the brain
KG Mountjoy - Adv Exp Med Biol, 2010 - Springer
Biological responses to pro-opiomelanocortin (POMC)-derived peptides administered in the
brain were documented in the 1950s but their molecular mechanisms of action only began …
brain were documented in the 1950s but their molecular mechanisms of action only began …
Synaptic changes induced by melanocortin signalling
The melanocortin system has a well-established role in the regulation of energy
homeostasis, but there is growing evidence of its involvement in memory, nociception, mood …
homeostasis, but there is growing evidence of its involvement in memory, nociception, mood …
Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes
KG Mountjoy - Biochemical Journal, 2010 - portlandpress.com
Melanocortin peptides, derived from POMC (pro-opiomelanocortin) are produced in the ARH
(arcuate nucleus of the hypothalamus) neurons and the neurons in the commissural NTS …
(arcuate nucleus of the hypothalamus) neurons and the neurons in the commissural NTS …
Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia
D Giuliani, C Mioni, D Altavilla, S Leone… - …, 2006 - academic.oup.com
Ischemic stroke is one of the main causes of death and disability. We investigated whether
melanocortin peptides, which have protective effects in severe hypoxic conditions, also …
melanocortin peptides, which have protective effects in severe hypoxic conditions, also …