It is now 30 years since the first report of a potent zinc-dependent histone deacetylase
(HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory …

Candida auris is a recently emerged multidrug-resistant fungal pathogen causing severe
illness in hospitalized patients. C. auris is most closely related to a few environmental or …

Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …

The emergence of drug-resistant fungi poses a continuously increasing threat to human
health. Despite advances in preventive care and diagnostics, resistant fungi continue to …

Fungal histone deacetylases (HDACs) are enzymes known for their crucial role in gene
expression regulation through histone deacetylation, leading to chromatin compaction and …

Chromatin structure is a major regulator of DNA-associated processes, such as transcription,
DNA repair, and replication. Histone post-translational modifications, or PTMs, play a key …

CARD9-related inherited immune disorders are a major risk factor for chronic disseminated
fungal infection. In addition to pathogens of Candida and dermatophytes, the environmental …

Candida auris is an emerging multidrug-resistant human fungal pathogen often refractory to
treatment by all classes of antifungal drugs. Amphotericin B (AmB) is a fungicidal drug that …

Fungi cause death of over 1.5 million people every year, while cutaneous mycoses are
among the most common infections in the world. Mycoses vary greatly in severity, there are …

Adaptation to changing environments and immune evasion is pivotal for fitness of
pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation is …