T-cell acute lymphoblastic leukemias (T-ALL) are immature lymphoid tumors localizing in the
bone marrow, mediastinum, central nervous system, and lymphoid organs. They account for …

T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

Ubiquitylation, a highly regulated post-translational modification, controls many cellular
pathways that are critical to cell homeostasis. Ubiquitin ligases recruit substrates and …

DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of
single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs. Somatic …

Controlled protein degradation is essential for the operation of a variety of cellular processes
including cell division, growth, and differentiation. Identification of the relations between …

Although chimeric antigen receptor (CAR) T cell immunotherapy has shown promising
significance in B cell malignancies, success against T cell malignancies remains …

MYC oncoprotein promotes cell proliferation and serves as the key driver in many human
cancers; therefore, considerable effort has been expended to develop reliable …

SKP2 (S-phase kinase-associated protein 2) is a member of the F-box family of substrate-
recognition subunits in the SCF ubiquitin-protein ligase complexes. It is associated with …

Notch signaling is an evolutionarily conserved pathway that is widely used for multiple
cellular events during development. Activation of the Notch pathway occurs when the ligand …

Background Psoriasis is a common chronic skin disorder. Pathologically, it features
abnormal epidermal proliferation, infiltrating inflammatory cells and increased angiogenesis …