Analyzing modern biomolecules: the revolution of nucleic-acid sequencing–Review

G Dorado, S Gálvez, TE Rosales, VF Vásquez… - Biomolecules, 2021 - mdpi.com
Recent developments have revolutionized the study of biomolecules. Among them are
molecular markers, amplification and sequencing of nucleic acids. The latter is classified into …

A global genomic analysis of Salmonella Concord reveals lineages with high antimicrobial resistance in Ethiopia

WL Cuypers, P Meysman, FX Weill… - Nature …, 2023 - nature.com
Antimicrobial resistant Salmonella enterica serovar Concord (S. Concord) is known to cause
severe gastrointestinal and bloodstream infections in patients from Ethiopia and Ethiopian …

Sequencing by avidity enables high accuracy with low reagent consumption

S Arslan, FJ Garcia, M Guo, MW Kellinger… - Nature …, 2024 - nature.com
We present avidity sequencing, a sequencing chemistry that separately optimizes the
processes of stepping along a DNA template and that of identifying each nucleotide within …

Exon capture museomics deciphers the nine-banded armadillo species complex and identifies a new species endemic to the Guiana Shield

M Barthe, L Rancilhac, MC Arteaga, A Feijó… - Systematic …, 2024 - academic.oup.com
The nine-banded armadillo (Dasypus novemcinctus) is the most widespread xenarthran
species across the Americas. Recent studies have suggested it is composed of 4 …

Is the mutation rate lower in genomic regions of stronger selective constraints?

H Liu, J Zhang - Molecular Biology and Evolution, 2022 - academic.oup.com
A study of the plant Arabidopsis thaliana detected lower mutation rates in genomic regions
where mutations are more likely to be deleterious, challenging the principle that …

Somatic mutations inferred from RNA-seq data highlight the contribution of replication timing to mutation rate variation in a model plant

PM Staunton, AJ Peters, C Seoighe - Genetics, 2023 - academic.oup.com
Variation in the rates and characteristics of germline and somatic mutations across the
genome of an organism is informative about DNA damage and repair processes and can …

Integrative analysis of whole genome sequencing and phenotypic resistance toward prediction of trimethoprim-sulfamethoxazole resistance in Staphylococcus aureus

D Nurjadi, E Zizmann, Q Chanthalangsy… - Frontiers in …, 2021 - frontiersin.org
As whole genome sequencing is becoming more accessible and affordable for clinical
microbiological diagnostics, the reliability of genotypic antimicrobial resistance (AMR) …

CARE 2.0: reducing false-positive sequencing error corrections using machine learning

F Kallenborn, J Cascitti, B Schmidt - BMC bioinformatics, 2022 - Springer
Background Next-generation sequencing pipelines often perform error correction as a
preprocessing step to obtain cleaned input data. State-of-the-art error correction programs …

Genome sequence assembly algorithms and misassembly identification methods

Y Meng, Y Lei, J Gao, Y Liu, E Ma, Y Ding, Y Bian… - Molecular biology …, 2022 - Springer
The sequence assembly algorithms have rapidly evolved with the vigorous growth of
genome sequencing technology over the past two decades. Assembly mainly uses the …

CARE: context-aware sequencing read error correction

F Kallenborn, A Hildebrandt, B Schmidt - Bioinformatics, 2021 - academic.oup.com
Motivation Error correction is a fundamental pre-processing step in many Next-Generation
Sequencing (NGS) pipelines, in particular for de novo genome assembly. However, existing …