Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

The skin epidermis is constantly renewed throughout life,. Disruption of the balance between
renewal and differentiation can lead to uncontrolled growth and tumour initiation. However …

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …

Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive
tumorigenesis. However, the origin of intratumoural functional heterogeneity between …

Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the
mammalian hippocampus. We used chronic in vivo imaging and followed genetically …

Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells
(SCs) populations contribute to wound healing. However, how SCs balance proliferation …

Skin architecture and function depend on diverse populations of epidermal cells and dermal
fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in …

Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype
of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an …