Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …

MicroRNAs are short regulatory RNAs that are able to post-transcriptionally modulate gene
expression and that have crucial roles in the control of physiological and pathological …

Abstract Background Cancer-associated fibroblasts (CAFs) have been widely reported to
promote tumor angiogenesis. However, the underlying mechanisms of the proangiogenic …

Melanoma cells release different types of extracellular vesicles (EVs) into the extracellular
milieu that are involved with communication and signaling in the tumor microenvironment …

Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic
benefits but the common emergence of drug resistance remains a challenge. We generated …

Formal staging of cancer is fundamental in providing clinicians and patients with prognostic
information, developing treatment strategies, and directing and analyzing clinical trials …

MicroRNAs (miRNAs) regulate gene expression by repressing translation or directing
sequence-specific degradation of complementary mRNA. Here, we report that expression of …

The incidence of cutaneous malignant melanoma has rapidly increased in recent years in all
parts of the world, and melanoma is a leading cause of cancer death. As even relatively …

Purpose: MicroRNAs (miRNA) have potential as diagnostic and prognostic biomarkers and
as therapeutic targets in cancer. We sought to establish the relationship between miRNA …

Background: The incidence of malignant melanoma is increasing faster than that for any
other cancer. Histological examination of skin excision biopsies remains the standard …