Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and
represents the major therapeutic target for treating metastatic prostate cancer (mPC) …

Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit
signals from their receptors to regulate gene expression and prevent apoptosis. Some …

Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell
responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity …

Abstract PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …

The RAS–mitogen activated protein kinase (MAPK) signalling pathway has long been
viewed as an attractive pathway for anticancer therapies, based on its central role in …

The androgen receptor (AR) signaling axis plays a critical role in the development, function
and homeostasis of the prostate. The classical action of AR is to regulate gene …

We used clinical tissue from lethal metastatic castration-resistant prostate cancer (CRPC)
patients obtained at rapid autopsy to evaluate diverse genomic, transcriptomic, and …

Protein arrays are described for screening of molecular markers and pathway targets in
patient matched human tissue during disease progression. In contrast to previous protein …