Selenium in thyroid disorders—essential knowledge for clinicians

KH Winther, MP Rayman, SJ Bonnema… - Nature Reviews …, 2020 - nature.com
In the 1990s, selenium was identified as a component of an enzyme that activates thyroid
hormone; since this discovery, the relevance of selenium to thyroid health has been widely …

Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease

MP Rayman - Proceedings of the nutrition society, 2019 - cambridge.org
Hashimoto's thyroiditis (HT) and Graves' disease (GD) are examples of autoimmune thyroid
disease (AITD), the commonest autoimmune condition. Antibodies to thyroid peroxidase …

Brazil nuts: Nutritional composition, health benefits and safety aspects

BR Cardoso, GBS Duarte, BZ Reis… - Food Research …, 2017 - Elsevier
Brazil nuts are among the richest selenium food sources, and studies have considered this
Amazonian nut as an alternative for selenium supplementation. Besides selenium, Brazil …

Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis

J Wichman, KH Winther, SJ Bonnema, L Hegedüs - Thyroid, 2016 - liebertpub.com
Background: Selenium supplementation may decrease circulating thyroid autoantibodies in
patients with chronic autoimmune thyroiditis (AIT), but the available trials are heterogenous …

Clinical relevance of environmental factors in the pathogenesis of autoimmune thyroid disease

WM Wiersinga - Endocrinology and metabolism, 2016 - synapse.koreamed.org
Genetic factors contribute for about 70% to 80% and environmental factors for about 20% to
30% to the pathogenesis of autoimmune thyroid disease (AITD). Relatives of AITD patients …

Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: a prospective randomized‐controlled trial

Y Hu, W Feng, H Chen, H Shi, L Jiang… - Clinical and …, 2021 - Wiley Online Library
Selenium (Se) is an essential trace element in human. Recent studies of Se
supplementation on the effect of Hashimoto's thyroiditis (HT) have been reported, but the …

Metabolism as a target for modulation in autoimmune diseases

N Huang, A Perl - Trends in immunology, 2018 - cell.com
Metabolic pathways are now well recognized as important regulators of immune
differentiation and activation, and thus influence the development of autoimmune diseases …

The role of selected trace elements in oxidoreductive homeostasis in patients with thyroid diseases

M Wróblewski, J Wróblewska, J Nuszkiewicz… - International journal of …, 2023 - mdpi.com
Impaired levels of selenium (Se), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn) and
iodine (I) in the organism may adversely affect the thyroid endocrine system. These trace …

Selenium supplementation in patients with Hashimoto thyroiditis: a systematic review and meta-analysis of randomized clinical trials

VV Huwiler, S Maissen-Abgottspon, Z Stanga… - Thyroid, 2024 - liebertpub.com
Background: Hashimoto thyroiditis (HT) is the most common cause of hypothyroidism in
iodine-sufficient areas. Selenium is an essential trace element required for thyroid hormone …

The role of selenium in thyroid gland pathophysiology

M Stuss, M Michalska-Kasiczak… - Endokrynologia …, 2017 - journals.viamedica.pl
It is now assumed that proper functioning of the thyroid gland (TG), beside iodine, requires
also a number of elements, including selenium, iron, zinc, copper, and calcium. In many …