Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents

J Deng, L Zhao, NY Zhang, NA Karrow… - … research/reviews in …, 2018 - Elsevier
Abstract Aflatoxin B 1 (AFB 1) widely contaminates staple food and feed crops and is well-
known as the most potent natural hepatocarcinogen in humans and domesticated animals …

Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

DW Nebert, AL Roe, MZ Dieter, WA Solis… - Biochemical …, 2000 - Elsevier
The chronology and history of characterizing the aromatic hydrocarbon [Ah] battery is
reviewed. This battery represents the Ah receptor (AHR)-mediated control of at least six, and …

Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms

F Regoli, ME Giuliani - Marine environmental research, 2014 - Elsevier
The antioxidant system of marine organisms consists of low molecular weight scavengers
and antioxidant enzymes which interact in a sophisticated network. Environmental pollutants …

Mechanisms that regulate production of reactive oxygen species by cytochrome P450

RC Zangar, DR Davydov, S Verma - Toxicology and applied pharmacology, 2004 - Elsevier
Mammalian cytochromes P450 (P450) are a family of heme-thiolate enzymes involved in the
oxidative metabolism of a variety of endogenous and exogenous lipophilic compounds …

Repression of gene expression by oxidative stress

Y Morel, R Barouki - Biochemical Journal, 1999 - portlandpress.com
Gene expression is modulated by both physiological signals (hormones, cytokines, etc.) and
environmental stimuli (physical parameters, xenobiotics, etc.). Oxidative stress appears to be …

Understanding the human health effects of chemical mixtures.

DO Carpenter, K Arcaro, DC Spink - Environmental health …, 2002 - ehp.niehs.nih.gov
Most research on the effects of chemicals on biologic systems is conducted on one chemical
at a time. However, in the real world people are exposed to mixtures, not single chemicals …

Antioxidative, anti-inflammatory and hepatoprotective effects of resveratrol on oxidative stress-induced liver damage in tilapia (Oreochromis niloticus)

R Jia, Y Li, L Cao, J Du, T Zheng, H Qian, Z Gu… - … and Physiology Part C …, 2019 - Elsevier
Resveratrol, a dietary polyphenol, has been shown to exert antioxidation, hepatoprotection,
anti-inflammation and immunostimulation. However, the effects and underlying mechanism …

Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity

L Bodin, C Verstuyft, DA Tregouet, A Robert, L Dubert… - Blood, 2005 - ashpublications.org
The aim of the study is to explore the contribution of genetic factors related either to drug
metabolism (cytochrome P450 2C9) or to drug target (vitamin K epoxide reductase) to …

Role of hydrogen peroxide and oxidative stress in healing responses

M Rojkind, JA Dominguez-Rosales, N Nieto… - Cellular and Molecular …, 2002 - Springer
Oxidative stress is a host defense mechanism whose involvement in maintaining
homeostasis and/or inducing disease has been widely investigated over the past decade …

Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells

J Athinarayanan, VS Periasamy, MA Alsaif… - Cell biology and …, 2014 - Springer
Silica (E551) is commonly used as an anti-caking agent in food products. The morphology
and the dimension of the added silica particles are not, however, usually stated on the food …