[HTML][HTML] B cell depletion therapies in autoimmune disease: advances and mechanistic insights
DSW Lee, OL Rojas, JL Gommerman - Nature reviews Drug discovery, 2021 - nature.com
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
[HTML][HTML] MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
Super-enhancer hypermutation alters oncogene expression in B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common B cell non-Hodgkin lymphoma
and remains incurable in around 40% of patients. Efforts to sequence the coding genome …
and remains incurable in around 40% of patients. Efforts to sequence the coding genome …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
[HTML][HTML] Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
Targeting B cell receptor signalling in cancer: preclinical and clinical advances
JA Burger, A Wiestner - Nature Reviews Cancer, 2018 - nature.com
B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …
immunity. BCR signalling also supports the survival and growth of malignant B cells in …
The generation of antibody-secreting plasma cells
The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …
A shift in lung macrophage composition is associated with COVID-19 severity and recovery
ST Chen, MD Park, DM Del Valle, M Buckup… - Science translational …, 2022 - science.org
Although it has been more than 2 years since the start of the coronavirus disease 2019
(COVID-19) pandemic, COVID-19 continues to be a worldwide health crisis. Despite the …
(COVID-19) pandemic, COVID-19 continues to be a worldwide health crisis. Despite the …
Regulatory circuits of T cell function in cancer
DE Speiser, PC Ho, G Verdeil - Nature Reviews Immunology, 2016 - nature.com
Recent progress in cancer immunotherapy emphasizes the importance of understanding
immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to …
immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to …