Shikimic acid is a natural product of industrial importance utilized as a precursor of the
antiviral Tamiflu. It is nowadays produced in multihundred ton amounts from the extraction of …

Roughly a third of the world's population is estimated to have latent Mycobacterium
tuberculosis infection, being at risk of developing active tuberculosis (TB) during their …

Abstract Anopheles gambiae, An. coluzzii, An. arabiensis, and An. funestus are major
vectors in high malaria endemic African regions. Various terpenoid classes form the main …

Promiscuous inhibition due to aggregate formation has been recognized as a major concern
in drug discovery campaigns. Here, we report some aggregators identified in a virtual …

In this study, we have investigated the enzyme shikimate 5-dehydrogenase from the
causative agent of tuberculosis, Mycobacterium tuberculosis. We have employed a mixture …

Background: The prevalence of drug-resistant organisms has steadily increased over the
past few decades worldwide. Especially in tuberculosis (TB) disease, the problems of co …

The number of drugs available for treatment of active tuberculosis is diminishing due to
increased multidrug resistance selection in Mycobacterium tuberculosis leading to multiple …

莽草酸激酶是莽草酸途径中的关键蛋白, 对结核分枝杆菌的生存至关重要.
本研究首先建立了结核分枝杆菌莽草酸激酶(Mycobacterium tuberculosis shikimate kinase …

Tuberculosis is caused by the bacterium Mycobacterium tuberculosis. The first line drugs
available for treatment of TB are isoniazid, rifamsin etc. Second line drugs are …

Tuberculosis (TB) still stands as one of the leading causes of mortality resulting from an
infectious agent. In part, this stems from the emergence of multidrug and extensive drug …