Convolutional nets for reconstructing neural circuits from brain images acquired by serial section electron microscopy

K Lee, N Turner, T Macrina, J Wu, R Lu… - Current opinion in …, 2019 - Elsevier
Neural circuits can be reconstructed from brain images acquired by serial section electron
microscopy. Image analysis has been performed by manual labor for half a century, and …

Topology-aware uncertainty for image segmentation

S Gupta, Y Zhang, X Hu… - Advances in Neural …, 2024 - proceedings.neurips.cc
Segmentation of curvilinear structures such as vasculature and road networks is challenging
due to relatively weak signals and complex geometry/topology. To facilitate and accelerate …

TeraVR empowers precise reconstruction of complete 3-D neuronal morphology in the whole brain

Y Wang, Q Li, L Liu, Z Zhou, Z Ruan, L Kong… - Nature …, 2019 - nature.com
Neuron morphology is recognized as a key determinant of cell type, yet the quantitative
profiling of a mammalian neuron's complete three-dimensional (3-D) morphology remains …

RoboEM: automated 3D flight tracing for synaptic-resolution connectomics

M Schmidt, A Motta, M Sievers, M Helmstaedter - Nature Methods, 2024 - nature.com
Mapping neuronal networks from three-dimensional electron microscopy (3D-EM) data still
poses substantial reconstruction challenges, in particular for thin axons. Currently available …

A survey of visualization and analysis in high‐resolution connectomics

J Beyer, J Troidl, S Boorboor… - Computer Graphics …, 2022 - Wiley Online Library
The field of connectomics aims to reconstruct the wiring diagram of Neurons and synapses
to enable new insights into the workings of the brain. Reconstructing and analyzing the …

Beyond neurons: computer vision methods for analysis of morphologically complex astrocytes

TA Syed, M Youssef, AL Schober, Y Kubota… - Frontiers in Computer …, 2024 - frontiersin.org
The study of the geometric organization of biological tissues has a rich history in the
literature. However, the geometry and architecture of individual cells within tissues has …

Barrio: customizable spatial neighborhood analysis and comparison for nanoscale brain structures

J Troidl, C Cali, E Gröller, H Pfister… - Computer Graphics …, 2022 - Wiley Online Library
High‐resolution electron microscopy imaging allows neuroscientists to reconstruct not just
entire cells but individual cell substructures (ie, cell organelles) as well. Based on these …

Biologically-constrained graphs for global connectomics reconstruction

B Matejek, D Haehn, H Zhu, D Wei… - Proceedings of the …, 2019 - openaccess.thecvf.com
Most current state-of-the-art connectome reconstruction pipelines have two major steps:
initial pixel-based segmentation with affinity prediction and watershed transform, and refined …

[HTML][HTML] Scalable interactive visualization for connectomics

D Haehn, J Hoffer, B Matejek, A Suissa-Peleg… - Informatics, 2017 - mdpi.com
Connectomics has recently begun to image brain tissue at nanometer resolution, which
produces petabytes of data. This data must be aligned, labeled, proofread, and formed into …

GLAM: Glycogen-derived Lactate Absorption Map for visual analysis of dense and sparse surface reconstructions of rodent brain structures on desktop systems and …

M Agus, D Boges, N Gagnon, PJ Magistretti… - Computers & …, 2018 - Elsevier
Human brain accounts for about one hundred billion neurons, but they cannot work properly
without ultrastructural and metabolic support. For this reason, mammalian brains host …