DNA topoisomerases as a drug target in Leishmaniasis: Structural and mechanistic insights
Leishmaniasis, caused by a protozoan parasite, is among humanity's costliest banes, owing
to the high mortality and morbidity ratio in poverty-stricken areas. To date, no vaccine is …
to the high mortality and morbidity ratio in poverty-stricken areas. To date, no vaccine is …
Demystifying the potential of inhibitors targeting DNA topoisomerases in unicellular protozoan parasites
S Lamba, A Roy - Drug Discovery Today, 2023 - Elsevier
Highlights•Parasitic diseases are a severe threat that needs to be dealt with.•DNA
topoisomerases are a group of enzymes essential for the survival of all organisms.• …
topoisomerases are a group of enzymes essential for the survival of all organisms.• …
Role of the Nucleotide Excision Repair endonuclease XPF in the kinetoplastid parasite Trypanosoma brucei
C Gómez-Liñán, M Sáez-Maldonado, LM Ruíz-Pérez… - bioRxiv, 2025 - biorxiv.org
The nucleotide excision repair (NER) mechanism is responsible for the removal of bulky
DNA damage such as pyrimidine dimers induced by ultraviolet light. The NER pathway …
DNA damage such as pyrimidine dimers induced by ultraviolet light. The NER pathway …
Similarity-based profiling of hydrazone-containing scaffolds active against leishmania amastigotes
JLA de Lima, SB de Abreu Pinto, RYP da Silva… - 2024 - chemrxiv.org
This review explores the potential of hydrazone-containing scaffolds as antileishmanial
agents, particularly targeting Leishmania amastigotes. Through a strategy focusing on the …
agents, particularly targeting Leishmania amastigotes. Through a strategy focusing on the …
Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome
Hyperproliferation driven by the protooncogene MYC may lead to tumor suppressor p53
activating DNA damage that has been presumed to derive from hypertranscription and over …
activating DNA damage that has been presumed to derive from hypertranscription and over …