Mitochondrial transcription factor A (mtTFA, mtTF1, TFAM) is an essential protein that binds
mitochondrial DNA (mtDNA) with and without sequence specificity to regulate both …

Mitochondrial biogenesis is regulated to adapt mitochondrial population to cell energy
demands. Mitochondrial transcription factor A (TFAM) performs several functions for mtDNA …

Tau is an essential protein that physiologically promotes the assembly and stabilization of
microtubules, and participates in neuronal development, axonal transport, and neuronal …

The packaging of mitochondrial DNA (mtDNA) into DNA-protein assemblies called
nucleoids provides an efficient segregating unit of mtDNA, coordinating mtDNA's …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …

Human mitochondrial DNA is transcribed by POLRMT with the help of two initiation factors,
TFAM and TFB2M. The current model postulates that the role of TFAM is to recruit POLRMT …

Substantial evidence indicates that mitochondrial impairment contributes to neuronal
dysfunction and vulnerability in disease states, leading investigators to propose that the …

As a consequence of recent discoveries of intimate involvement of mitochondria with key
cellular processes, there has been a resurgence of interest in all aspects of mitochondrial …

The human genome comprises large chromosomes in the nucleus and mitochondrial DNA
(mtDNA) housed in the dynamic mitochondrial network. Human cells contain up to …

High mitochondrial DNA (mtDNA) copy numbers are essential for oogenesis and
embryogenesis and correlate with fertility of oocytes and viability of embryos. To understand …