CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Clustering Molecular Dynamics trajectories is a common analysis that allows grouping
together similar conformations. Several algorithms have been designed and optimized to …

Given the key role played by ClC-K chloride channels in kidney and inner ear physiology
and pathology, they can be considered important targets for drug discovery. Indeed, ClC-Ka …

Background and Purpose Although chloride channels are involved in several physiological
processes and acquired diseases, the availability of compounds selectively targeting CLC …

The molecular basis of chloride transport varies all along the nephron depending on the
tubular segments especially in the apical entry of the cell. The major chloride exit pathway …

Mutations in the CLCN1 gene are the primary cause of non-dystrophic Hereditary Myotonia
in several animal species. However, there are no reports of Hereditary Myotonia in pigs to …

The many mechanisms governing NaCl absorption in the diverse parts of the renal tubule
have been largely elucidated, although some of them, as neutral NaCl absorption across the …

Pathological missense mutations in CLCNKB gene give a wide spectrum of clinical
phenotypes in Bartter syndrome type III patients. Molecular analysis of the mutated ClC‐Kb …

Type III and IV Bartter syndromes (BS) are rare kidney tubulopathies caused by loss-of-
function mutations in the CLCNKB and BSND genes coding respectively for the ClC-Kb …

GABAA receptors are pentameric ligand-gated ion channels that serve as major inhibitory
neurotransmitter receptors in the mammalian brain and the target of numerous clinically …