In-vitro model systems for the study of human embryo–endometrium interactions

CHE Weimar, EDP Uiterweer, G Teklenburg… - Reproductive …, 2013 - Elsevier
Implantation requires highly orchestrated interactions between the developing embryo and
maternal endometrium. The association between abnormal implantation and reproductive …

How mechanical forces change the human endometrium during the menstrual cycle in preparation for embryo implantation

AK Sternberg, VU Buck, I Classen-Linke, RE Leube - Cells, 2021 - mdpi.com
The human endometrium is characterized by exceptional plasticity, as evidenced by rapid
growth and differentiation during the menstrual cycle and fast tissue remodeling during early …

A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines

M Rothbauer, N Patel, H Gondola, M Siwetz… - Scientific reports, 2017 - nature.com
The human placenta plays a crucial role as the interface between mother and fetus. It
represents a unique tissue that undergoes morphological as well as functional changes on …

Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation.

MN Fukuda, T Sato, J Nakayama, G Klier… - Genes & …, 1995 - genesdev.cshlp.org
Two human epithelial cell lines, trophoblastic teratocarcinoma HT-H and endometrial
adenocarcinoma SNG-M cells, adhere to each other at their respective apical cell surfaces …

Intrauterine administration of autologous peripheral blood mononuclear cells promotes implantation rates in patients with repeated failure of IVF–embryo transfer

S Yoshioka, H Fujiwara, T Nakayama… - Human …, 2006 - academic.oup.com
BACKGROUND: There are few effective approaches to infertile patients with repeated failure
in IVF–embryo transfer therapy. Since recent evidence suggests that some populations of …

Measuring cell adhesion forces with the atomic force microscope at the molecular level

M Benoit, HE Gaub - Cells Tissues Organs, 2002 - karger.com
In the past 25 years many techniques have been developed to characterize cell adhesion
and to quantify adhesion forces. Atomic force microscopy (AFM) has been used to measure …

Interactions between trophoblast and uterine epithelium: monitoring of adhesive forces.

M Thie, R Röspel, W Dettmann, M Benoit… - Human reproduction …, 1998 - academic.oup.com
At embryo implantation, it is postulated that the initial contact between blastocyst and
maternal tissues is by adhesion of the trophoblast to the uterine epithelium. This cell-to-cell …

A novel model of human implantation: 3D endometrium-like culture system to study attachment of human trophoblast (Jar) cell spheroids

H Wang, F Pilla, S Anderson… - Molecular human …, 2012 - academic.oup.com
There is an urgent need to develop optimized experimental models to examine human
implantation. These studies aimed to (i) establish a human endometrium-like three …

Organoids to model the endometrium: implantation and beyond

TM Rawlings, K Makwana, M Tryfonos… - Reproduction and …, 2021 - raf.bioscientifica.com
Despite advances in assisted reproductive techniques in the 4 decades since the first
human birth after in vitro fertilisation, 1–2% of couples experience recurrent implantation …

Rapid generation of functional nanovesicles from human trophectodermal cells for embryo attachment and outgrowth

QH Poh, A Rai, M Pangestu, LA Salamonsen… - …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are important mediators of embryo attachment and outgrowth
critical for successful implantation. While EVs have garnered immense interest in their …