GABAA receptors as targets for treating affective and cognitive symptoms of depression
In the past 20 years, our understanding of the pathophysiology of depression has evolved
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …
Studying synaptic connectivity and strength with optogenetics and patch-clamp electrophysiology
LE Linders, LF Supiot, W Du, R D'Angelo… - International journal of …, 2022 - mdpi.com
Over the last two decades the combination of brain slice patch clamp electrophysiology with
optogenetic stimulation has proven to be a powerful approach to analyze the architecture of …
optogenetic stimulation has proven to be a powerful approach to analyze the architecture of …
Parvalbumin-positive interneurons in the medial prefrontal cortex regulate stress-induced fear extinction impairments in male and female rats
AN Binette, J Liu, H Bayer, KL Crayton… - Journal of …, 2023 - Soc Neuroscience
Stress has profound effects on fear extinction, a form of learning that is essential to
behavioral therapies for trauma-related and stressor-related disorders. Recent work reveals …
behavioral therapies for trauma-related and stressor-related disorders. Recent work reveals …
Sex dependence of opioid-mediated responses to subanesthetic ketamine in rats
Subanesthetic ketamine is increasingly used for the treatment of varied psychiatric
conditions, both on-and off-label. While it is commonly classified as an N-methyl D-aspartate …
conditions, both on-and off-label. While it is commonly classified as an N-methyl D-aspartate …
Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice
D Chen, Q Lou, XJ Song, F Kang, A Liu… - Nature …, 2024 - nature.com
Anxiety-associated symptoms following acute stress usually become extinct gradually within
a period of time. However, the mechanisms underlying how individuals cope with stress to …
a period of time. However, the mechanisms underlying how individuals cope with stress to …
Clinical investigations of compounds targeting metabotropic glutamate receptors
JM Witkin, KP Pandey, JL Smith - Pharmacology Biochemistry and …, 2022 - Elsevier
Pharmacological modulation of glutamate has long been considered to be of immense
therapeutic utility. The metabotropic glutamate receptors (mGluRs) are potential targets for …
therapeutic utility. The metabotropic glutamate receptors (mGluRs) are potential targets for …
Prefrontal interneurons: populations, pathways, and plasticity supporting typical and disordered cognition in rodent models
Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …
Dynorphin/kappa-opioid receptor regulation of excitation-inhibition balance toggles afferent control of prefrontal cortical circuits in a pathway-specific manner
The medial prefrontal cortex (mPFC) controls behavior via connections with limbic excitatory
afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin …
afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin …
Experience-dependent information routing through the basolateral amygdala shapes behavioral outcomes
P Antonoudiou, BT Stone, PLW Colmers… - Cell reports, 2024 - cell.com
It is well established that the basolateral amygdala (BLA) is an emotional processing hub
that governs a diverse repertoire of behaviors. Selective engagement of a heterogeneous …
that governs a diverse repertoire of behaviors. Selective engagement of a heterogeneous …
Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure
Clinical and preclinical studies have identified somatostatin (SST)-positive interneurons as
critical elements that regulate the vulnerability to stress-related psychiatric disorders …
critical elements that regulate the vulnerability to stress-related psychiatric disorders …