The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …

One of the most compelling features of dry eye disease (DED) is that it occurs more
frequently in women than men. In fact, the female sex is a significant risk factor for the …

WRKY transcription factors constitute one of the largest transcription factor families in plants,
and play crucial roles in plant growth and development, defense regulation and stress …

Plants as sessile organisms are exposed to persistently changing stress factors. The primary
stresses such as drought, salinity, cold and hot temperatures and chemicals are …

The heat shock proteins (HSPs) induced by cell stress are expressed at high levels in a wide
range of tumors and are closely associated with a poor prognosis and resistance to therapy …

We used a cellular system to elucidate the molecular determinants of the large immunophilin
FK506-binding proteins (FKBP) 51 and-52 for their action on the glucocorticoid receptor in …

The hypothalamic‐pituitary‐adrenal (HPA) axis regulates circulating levels of glucocorticoid
hormones, and is the major neuroendocrine system in mammals that provides a rapid …

In nature, plants are constantly exposed to many transient, but recurring, stresses. Thus, to
complete their life cycles, plants require a dynamic balance between capacities to recover …

In the last decade, the molecular chaperone HSP90 has emerged as an important target in
cancer therapeutics and has subsequently become the focus of several drug discovery and …

The glucocorticoid receptor is a known regulator of a variety of physiological processes. Its
mode of action is well defined: upon hormone binding, it undergoes a conformational …