Over the years, various liver-derived in vitro model systems have been developed to enable
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …

The use of primary hepatocytes is now well established for both studies of drug metabolism
and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for …

A potential approach to facilitate the performance of implanted hepatocytes is to enable their
aggregation and re‐expression of their differentiated function prior to implantation. Here we …

We have investigated the effect of cytokines, including interleukin-6 (11-6), interleukin-lα (II-
lα), and tumor necrosis factor-alpha (TNF-α), on the inducible expression of cytochrome …

The dynamics of gene expression are fundamental to the coordination of cellular responses.
Measurement of temporal gene expression patterns is currently limited to destructive low …

When designing an extracorporeal hybrid liver support device, special attention should be
paid to providing the architectural basis for reconstructing a proper cellular …

We have investigated the involvement of interleukin-6 (IL-6) in the induction of the gene
encoding the acute-phase protein human C-reactive protein (hCRP). In transgenic mice the …

An in vitro model for growth and differentiation of the metacestode tissue of the tapeworm
Echinococcus multilocularis is described. This model simulates the organotropism of the …

With a view to initiating clinical trials, cell morphology and function for a newly developed
artificial liver support system employing highly functional human liver cell line, FLC-7 …

This is the report of the forty-fifth of a series of workshops organised by the European Centre
for the Validation of Alternative Methods (ECVAM). ECVAM's main goal, as defined in 1993 …