Influence of food on paediatric gastrointestinal drug absorption following oral administration: a review
HK Batchelor - Children, 2015 - mdpi.com
The objective of this paper was to review existing information regarding food effects on drug
absorption within paediatric populations. Mechanisms that underpin food–drug interactions …
absorption within paediatric populations. Mechanisms that underpin food–drug interactions …
Sex effect on average bioequivalence
M Ibarra, M Vázquez, P Fagiolino - Clinical therapeutics, 2017 - Elsevier
Purpose Generic formulations are by far the most prescribed drugs. This scenario is highly
beneficial for society because medication expenses are significantly reduced after expiration …
beneficial for society because medication expenses are significantly reduced after expiration …
Pharmacokinetics of lopinavir/ritonavir and efavirenz in food insecure HIV‐infected pregnant and breastfeeding women in Tororo, Uganda
IH Bartelink, RM Savic, J Mwesigwa… - The Journal of …, 2014 - Wiley Online Library
Pregnancy and food insecurity may impact antiretroviral (ART) pharmacokinetics (PK),
adherence and response. We sought to quantify and characterize the PK of …
adherence and response. We sought to quantify and characterize the PK of …
The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo …
Background: Malnutrition may impact the pharmacokinetics (PKs) of antiretroviral
medications and virologic responses in HIV-infected children. The authors therefore …
medications and virologic responses in HIV-infected children. The authors therefore …
Paediatric abacavir–lamivudine fixed-dose dispersible tablets and ritonavir-boosted lopinavir granules in neonates exposed to HIV (PETITE study): an open-label, two …
Background Existing solid antiretroviral fixed-dose combination formulations are preferred
over liquid formulations in children, but their suitability for neonates is unknown. We …
over liquid formulations in children, but their suitability for neonates is unknown. We …
Pharmacokinetics and safety of the abacavir/lamivudine/lopinavir/ritonavir fixed-dose granule formulation (4-in-1) in neonates: PETITE study
Background: Antiretroviral options for neonates (younger than 28 days) should be
expanded. We evaluated the pharmacokinetics, safety, and acceptability of the" 4-in-1" fixed …
expanded. We evaluated the pharmacokinetics, safety, and acceptability of the" 4-in-1" fixed …
Leveraging physiologically based pharmacokinetic modeling to optimize dosing for lopinavir/ritonavir with rifampin in pediatric patients
Abstract Study Objective Treatment of HIV and tuberculosis co‐infection leads to significant
mortality in pediatric patients, and treatment can be challenging due to the clinically …
mortality in pediatric patients, and treatment can be challenging due to the clinically …
Sex-by-formulation interaction assessed through a bioequivalence study of efavirenz tablets
M Ibarra, L Magallanes, M Lorier, M Vázquez… - European Journal of …, 2016 - Elsevier
Although sex-related differences in gastrointestinal physiology have been vastly reported, its
impact on drug oral bioavailability and bioequivalence (product discrimination) is often …
impact on drug oral bioavailability and bioequivalence (product discrimination) is often …
Effect of food on the pharmacokinetics of the oral docetaxel tablet formulation ModraDoc006 combined with ritonavir (ModraDoc006/r) in patients with advanced solid …
MAC Vermunt, VA de Weger, JM Janssen… - Drugs in R&D, 2021 - Springer
Introduction ModraDoc006 is a novel docetaxel tablet formulation that is co-administrated
with the cytochrome P450 3A4 and P-glycoprotein inhibitor ritonavir (r): ModraDoc006/r …
with the cytochrome P450 3A4 and P-glycoprotein inhibitor ritonavir (r): ModraDoc006/r …
Pharmacokinetics, Safety, and Bioequivalence of 2 Lopinavir/Ritonavir (200/50 mg) Tablets in Healthy Chinese Volunteers: Effect of Food on Absorption
W Zhang, L Lin, W Fu, D Bao, Q Zhang… - Clinical …, 2023 - Wiley Online Library
Lopinavir/ritonavir is an important protease inhibitor for treating HIV‐1 infection in patients
aged> 2 years in combination with other antiretrovirals. The antiviral activity of …
aged> 2 years in combination with other antiretrovirals. The antiviral activity of …