Perturbation of a biological system with small molecules to achieve a desired phenotype or
activity is commonly referred as chemical genetics. In pharmaceutical discovery, this …

Protein kinases are a protein family that plays an important role in several complex diseases
such as cancer and cardiovascular and immunological diseases. Protein kinases have …

There has been a growing interest in multitask prediction in chemoinformatics, helped by the
increasing use of deep neural networks in this field. This technique is applied to multitarget …

Abstract signatureSearch is an R/Bioconductor package that integrates a suite of existing
and novel algorithms into an analysis environment for gene expression signature (GES) …

This chapter describes the volume and velocity of the data‐driven research for toxicology
have been well recognized by multiple screening and data‐sharing projects. It describes the …

Aging is the dominant risk factor for most chronic diseases. Development of antiaging
interventions offers the promise of preventing many such illnesses simultaneously. Cellular …

Background With the increasing development of biotechnology and information technology,
publicly available data in chemistry and biology are undergoing explosive growth. Such …

The protein eL38 is one of the smallest proteins of the mammalian ribosome, which is a
component of its large (60S) subunit. The haploinsufficiency of eL38 in mice leads to the Tail …

Drug discovery typically involves investigation of a set of compounds (eg drug screening
hits) in terms of target, disease, and bioactivity. CSgator is a comprehensive analytic tool for …

This study presents an analysis of the small molecule bioactivity profiles across large
quantities of diverse protein families represented in PubChem BioAssay. We compared the …