The demonstration that dopamine loss is the key pathological feature of Parkinson's disease
(PD), and the subsequent introduction of levodopa have revolutionalized the field of PD …

Stem cells are a relevant source of information about cellular differentiation, molecular
processes and tissue homeostasis, but also one of the most putative biological tools to treat …

Recent advances in deriving induced pluripotent stem (iPS) cells from patients offer new
possibilities for biomedical research and clinical applications, as these cells could be used …

Identification and use of cell surface cluster of differentiation (CD) biomarkers have enabled
much scientific and clinical progress. We identify a CD surface antigen code for the neural …

Mesodiencephalic dopaminergic neurons control voluntary movement and reward based
behaviours. Their dysfunction can lead to neurological disorders, including Parkinson's …

Considerable practical hurdles must be overcome prior to the broad application of stem cell
therapies. We outline challenges that may vary across different models of cell therapy …

Background aims Since human embryonic stem cells and human fetal neural stem cells
have immune rejection and ethical issues, recent advancements in induced pluripotent stem …

Parkinson's Disease (PD) is a progressive degenerative disease characterized by tremor,
bradykinesia, rigidity and postural instability. There are approximately 7–10 million PD …

The production of dopaminergic (DA) neurons from stem cells holds a great promise for
future clinical treatment of neurodegenerative diseases, such as Parkinson's disease (PD) …

Background aims Cholinergic neurons are very important cells in spinal cord injuries
because of the deficits in motor, autonomic and sensory neurons. In this study, bone marrow …