Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of
several physiological processes in both animals and plants. In the last century, it was …

Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been
retained throughout evolution such that it may be or may have been present in every species …

Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation
is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N …

Mitophagy is a type of selective macroautophagy/autophagy that degrades dysfunctional or
excessive mitochondria. Regulation of this process is critical for maintaining cellular …

Oxygen‐free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS),
are known by their “double‐sided” nature in biological systems. The beneficial effects of …

Mitochondrial fission and mitophagy are considered key processes involved in the
pathogenesis of cardiac microvascular ischemia reperfusion (IR) injury although the …

Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through poorly defined mechanisms. Melatonin supplementation has been …

The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

Ripk3-required necroptosis and mitochondria-mediated apoptosis are the predominant
types of cell death that largely account for the development of cardiac ischemia reperfusion …

Ischemia‐reperfusion injury (IRI) has indeed been shown as a main complication of
hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of …