Early studies in mouse neurodevelopment led to the discovery of the RE1 Silencing
Transcription Factor (REST) and its role as a master repressor of neuronal gene expression …

Hox gene clusters encode transcription factors that drive regional specialization during
animal development: for example the Hox factor Ubx is expressed in the insect metathoracic …

Position weight matrix (PWM) is the traditional motif model representing the transcription
factor (TF) binding sites. It proposes that the positions contribute independently to TFs …

Abstract Background Repressor element 1 (RE1) silencing transcription factor (REST) is a
transcriptional repressor abundantly expressed in aging human brains. It is known to …

The binding motifs of many transcription factors (TFs) comprise a higher degree of
complexity than a single position weight matrix model permits. Additional complexity is …

Motivation High-throughput chromatin immunoprecipitation (ChIP) sequencing-based
assays capture genomic regions associated with the profiled transcription factor (TF). ChIP …

The establishment of centromeric chromatin and its propagation by the centromere-specific
histone CENPA is mediated by epigenetic mechanisms in most eukaryotes. DNA replication …

The most popular model for the search of ChIP-seq data for transcription factor binding sites
(TFBS) is the positional weight matrix (PWM). However, this model does not take into …

High-throughput sequencing-based assays measure different biochemical activities
pertaining to gene regulation, genome-wide. These activities include transcription factor (TF) …

Аннотация Технология ChIP-seq, основанная на иммунопреципитации хроматина
(ChIP), позволяет картировать набор геномных локусов (пиков), содержащих сайты …