Metronomic (low-dose, long-term and frequently administered) chemotherapy has attracted
renewed interest for the past few years, in particular because of possible positive …

Melanoma is a progressive disease that claims many lives each year due to lack of
therapeutics effective for the long‐term treatment of patients. Currently, the best treatment …

The introduction of the “maximum tolerated dose” in usual treatment protocols (and its
concomitant overt toxicity) made necessary the imposition of rest periods between cycles of …

The incidence of malignant melanoma is increasing at an alarming rate globally. Poor
prognosis and extraordinarily low survival rates of malignant melanoma necessitates the …

Problems associated with the administration of anticancer drugs, such as limited solubility,
poor biodistribution, lack of selectivity, and healthy tissue damage, can be overcome by the …

Melanoma is a common and deadly tumor that upon metastasis to the central nervous
system (CNS) has median survival duration of less than 5 months. Activation of the signal …

The structure and the in vitro behavior of liposomes filled with the cytotoxic drug doxorubicin
(Doxo) and functionalized on the external surface with a branched moiety containing four …

Tie2 receptor is a receptor tyrosine kinase that plays important roles in vascular
angiogenesis, and also highly expressed by a number of cancer cells. In this study, we …

Metronomic chemotherapy has been advocated recently as a novel chemotherapeutic
regimen. Polyethylene glycol (PEG)‐coated liposomes are well known to accumulate in …

Arginine-glycine-aspartate (RGD) has been shown to possess a strong affinity for the
integrins overexpressed in tumor cells, especially during tumor invasion, angiogenesis and …