The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Depression is a common mental disorder characterized by heterogeneous cognitive and
behavioral symptoms. The emerging research paradigm of functional connectomics has …

What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …

Purpose Anhedonia is a core symptom of major depressive disorder (MDD), which has
important functional consequences for the patient. This post hoc analysis investigated the …

Major depressive disorder (MDD) is a very prevalent mental disorder that imposes an
enormous burden on individuals, society, and health care systems. Most patients benefit …

Natural psychedelic compounds are emerging as potential novel therapeutics in psychiatry.
This review will discuss how natural psychedelics exert their neurobiological therapeutic …

The serotonin deficit hypothesis explanation for major depressive disorder (MDD) has
persisted among clinicians and the general public alike despite insufficient supporting …

Major depressive disorder is a heterogeneous diagnostic category with multiple available
treatments. With the goal of optimizing treatment selection, researchers are developing …

Subthreshold depression (StD) is associated an increased risk of developing major
depressive disorder (MDD) and suicidality. Suicidality could be linked to distress intolerance …

Abstract Treatment outcomes widely vary for individuals diagnosed with major depressive
disorder, implicating a need for deeper understanding of the biological mechanisms …