Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

[HTML][HTML] Hydrogen sulfide chemical biology: pathophysiological roles and detection

GK Kolluru, X Shen, SC Bir, CG Kevil - Nitric oxide, 2013 - Elsevier
Hydrogen sulfide (H 2 S) is the most recent endogenous gasotransmitter that has been
reported to serve many physiological and pathological functions in different tissues. Studies …

Hydrogen sulphide and its therapeutic potential

C Szabó - Nature reviews Drug discovery, 2007 - nature.com
Hydrogen sulphide (H2S) is increasingly being recognized as an important signalling
molecule in the cardiovascular and nervous systems. The production of H2S from l-cysteine …

Hydrogen sulfide: its production, release and functions

H Kimura - Amino acids, 2011 - Springer
Abstract Hydrogen sulfide (H 2 S), which is a well-known toxic gas, has been recognized as
a signal molecule as well as a cytoprotectant. It is produced by three enzymes, cystathionine …

Hydrogen sulfide mediates cardioprotection through Nrf2 signaling

JW Calvert, S Jha, S Gundewar, JW Elrod… - Circulation …, 2009 - Am Heart Assoc
Rationale: The recent emergence of hydrogen sulfide (H2S) as a potent cardioprotective
signaling molecule necessitates the elucidation of its cytoprotective mechanisms. Objective …

[HTML][HTML] Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6

J Yang, P Minkler, D Grove, R Wang, B Willard… - Communications …, 2019 - nature.com
Hydrogen sulfide (H2S) plays important roles in metabolism and health. Its enzymatic
generation from sulfur-containing amino acids (SAAs) is well characterized. However, the …

Hydrogen sulfide: an emerging precision strategy for gas therapy

H Ding, J Chang, F He, S Gai… - Advanced Healthcare …, 2022 - Wiley Online Library
Advances in nanotechnology have enabled the rapid development of stimuli‐responsive
therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H2S) is a significant …

Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations

EJ Calabrese - Pharmacological Research, 2016 - Elsevier
This article provides the first extensive documentation of the dose response features of pre-
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …