Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

S Nooraei, H Bahrulolum, ZS Hoseini… - Journal of …, 2021 - Springer
Virus-like particles (VLPs) are virus-derived structures made up of one or more different
molecules with the ability to self-assemble, mimicking the form and size of a virus particle but …

Virus-like particle vaccinology, from bench to bedside

MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …

[HTML][HTML] Advancements in vaccine adjuvants: the journey from alum to nano formulations

SS Moni, SI Abdelwahab, A Jabeen, ME Elmobark… - Vaccines, 2023 - mdpi.com
Vaccination is a groundbreaking approach in preventing and controlling infectious diseases.
However, the effectiveness of vaccines can be greatly enhanced by the inclusion of …

Public health risks associated with hepatitis E virus (HEV) as a food‐borne pathogen

EFSA Panel on Biological Hazards (BIOHAZ)… - Efsa …, 2017 - Wiley Online Library
Hepatitis E virus (HEV) is an important infection in humans in EU/EEA countries, and over
the last 10 years more than 21,000 acute clinical cases with 28 fatalities have been notified …

In vitro assembly of virus-like particles and their applications

DT Le, KM Müller - Life, 2021 - mdpi.com
Virus-like particles (VLPs) are increasingly used for vaccine development and drug delivery.
Assembly of VLPs from purified monomers in a chemically defined reaction is advantageous …

Adjuvant formulations for virus-like particle (VLP) based vaccines

V Cimica, JM Galarza - Clinical immunology, 2017 - Elsevier
The development of virus-like particle (VLP) technology has had an enormous impact on
modern vaccinology. In order to optimize the efficacy and safety of VLP-based vaccines …

Escherichia coli-derived virus-like particles in vaccine development

X Huang, X Wang, J Zhang, N Xia, Q Zhao - npj Vaccines, 2017 - nature.com
Recombinant virus-like particle-based vaccines are composed of viral structural proteins
and mimic authentic native viruses but are devoid of viral genetic materials. They are the …

Use of plant viruses and virus-like particles for the creation of novel vaccines

I Balke, A Zeltins - Advanced drug delivery reviews, 2019 - Elsevier
In recent decades, the development of plant virology and genetic engineering techniques
has resulted in the construction of plant virus-based vaccines for protection against different …

The development of a recombinant hepatitis E vaccine HEV 239

SW Li, Q Zhao, T Wu, S Chen, J Zhang… - Human vaccines & …, 2015 - Taylor & Francis
Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis worldwide. A
recombinant hepatitis E vaccine, HEV 239, has been licensed in China for immunizing …

[HTML][HTML] Hepatitis B core-based virus-like particles: A platform for vaccine development in plants

MM Vahdat, F Hemmati, A Ghorbani, D Rutkowska… - Biotechnology …, 2021 - Elsevier
Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral
capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core …