Nonlinear effects of nanoparticles: biological variability from hormetic doses, small particle sizes, and dynamic adaptive interactions

IR Bell, JA Ives, BJ Wayne - Dose-Response, 2014 - journals.sagepub.com
Researchers are increasingly focused on the nanoscale level of organization where
biological processes take place in living systems. Nanoparticles (NPs, eg, 1–100 nm …

[HTML][HTML] Therapeutic potential of arsenic trioxide (ATO) in treatment of hepatocellular carcinoma: Role of oxidative stress in ATO-induced apoptosis

EB Dugo, CG Yedjou, JJ Stevens… - Annals of clinical …, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC), the dominant form of primary liver cancer, is the sixth most
common cancer in the world with more than 700,000 people diagnosed annually. Arsenic …

[PDF][PDF] Nanoparticle characterization of traditional homeopathically-manufactured Gelsemium sempervirens medicines and placebo controls

IR Bell, S Muralidharan… - J Nanomedine …, 2015 - researchgate.net
Multiple studies have observed nanostructures in traditionally-manufactured homeopathic
medicines. Homeopathy is a 200-year-old system of complementary and alternative …

[PDF][PDF] p53 介导的线粒体凋亡通路在燃煤型砷中毒大鼠肝损伤中的作用

谢婷婷, 张爱华 - 中国药理学与毒理学杂志, 2014 - cjpt.magtechjournal.com
目的了解燃煤型砷中毒大鼠肝细胞凋亡情况及p53 介导的线粒体凋亡通路在砷致肝损伤中的
作用. 方法Wistar 大鼠喂饲含砷量分别为0, 25, 50 和100 mg· kg-1 的饲料, 连续90 d …

Dual effects of arsenic trioxide on tumor cells and the potential underlying mechanisms

X Zhang, D Yu, H Geng, F Li, L Lv… - Oncology …, 2018 - spandidos-publications.com
The human ether‑a‑go‑go related gene (hERG) encodes the rapid delayed rectifier K+
channel. hERG not only serves an important role in heart muscle and cardiomyocyte …

[PDF][PDF] 毒物兴奋效应与神经保护

张超, 陈圣慧, 何承伟, 王一涛 - 科技导报, 2015 - kjdb.org
摘要毒物兴奋效应(hormesis) 指有毒物质或处理因素在低剂量或低水平时对生物体表现为有利
作用, 但在高剂量或高水平时表现出其相反作用的双相剂量效应, 可视为细胞或机体在不利环境 …

[HTML][HTML] Combined effect of arsenic trioxide and radiation on physical properties of hemoglobin biopolymer

AA Saad-El-Din, ZH El-Tanahy, SN El-Sayed… - Journal of Radiation …, 2014 - Elsevier
Abstract Arsenic trioxide (As 2 O 3) has been recently established as one of the most
effective drugs for the treatment of patients with acute promyelocytic leukemia. However, it …

HEp-2 cell line as an experimental model to evaluate genotoxic effects of pentavalent inorganic arsenic

NB Andrioli, G Chaufan, I Coalova, MC Molina… - 2017 - notablesdelaciencia.conicet.gov.ar
Early detection of toxic events induced by xenobiotics is necessary for a proper assessment
of human risk after the exposure to those agents. The aim of this work was to evaluate the …

HEp-2 como modelo experimental para evaluar los efectos genotóxicos del arsénico inorgánico pentavalente

NB Andrioli, G Chaufan, I Coalova… - BAG. Journal of …, 2017 - SciELO Argentina
Early detection of toxic events induced by xenobiotics is necessary for a proper assessment
of human risk after the exposure to those agents. The aim of this work was to evaluate the …

Endoplasmic Reticulum Stress and Autophagy in Cancer

ML Tan, HK Tan, TST Muhammad - Cancer Immunology: A Translational …, 2020 - Springer
Endoplasmic Reticulum stress (ER stress) is a condition whereby unfolded and misfolded
proteins accumulate in the ER lumen as a result of perturbation of the ER homeostasis …