Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit

H Ishimoto, RB Jaffe - Endocrine reviews, 2011 - academic.oup.com
Continuous efforts have been devoted to unraveling the biophysiology and development of
the human fetal adrenal cortex, which is structurally and functionally unique from other …

Family of melanocortin receptor (MCR) genes in mammals—mutations, polymorphisms and phenotypic effects

M Switonski, M Mankowska, S Salamon - Journal of applied genetics, 2013 - Springer
The melanocortin receptor gene family consists of five single-exon members, which are
located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human …

MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family

LF Chan, TR Webb, TT Chung… - Proceedings of the …, 2009 - National Acad Sciences
The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R–
MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic …

Minireview: the melanocortin 2 receptor accessory proteins

TR Webb, AJL Clark - Molecular endocrinology, 2010 - academic.oup.com
The melanocortin 2 receptor (MC2R) accessory protein, MRAP, is one of a growing number
of G protein-coupled receptor accessory proteins that have been identified in recent years …

ACTH receptor (MC2R) specificity: what do we know about underlying molecular mechanisms?

D Fridmanis, A Roga, J Klovins - Frontiers in Endocrinology, 2017 - frontiersin.org
Coincidentally, the release of this Research Topic in Frontiers in Endocrinology takes place
25 years after the discovery of the adrenocorticotropic hormone receptor (ACTHR) by …

Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology

NNA Berruien, CL Smith - Gene, 2020 - Elsevier
Melanocortin-2 receptor accessory protein (MRAP) has an unusual dual topology and
influences the expression, localisation, signalling and internalisation of the melanocortin …

Molecular evolution of GPCRs: melanocortin/melanocortin receptors

RM Dores, RL Londraville, J Prokop… - Journal of …, 2014 - jme.bioscientifica.com
The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are
activated by melanocortin ligands derived from the proprotein, proopiomelanocortin …

Melanocortin receptors and their accessory proteins

SN Cooray, AJL Clark - Molecular and cellular endocrinology, 2011 - Elsevier
The melanocortin receptor family consists of 5 members which belong to the GPCR
superfamily. Their specific ligands, the melanocortins are peptide hormones which are …

Role of melanocortin receptor accessory proteins in the function of zebrafish melanocortin receptor type 2

MJ Agulleiro, S Roy, E Sánchez, S Puchol… - Molecular and Cellular …, 2010 - Elsevier
In this paper, we identify three different MRAPs in zebrafish, zfMRAP1, zfMRAP2a and
zfMRAP2b, and demonstrate that zfMC2R is not functional in the absence of MRAP …

ACTH-dependent ultradian rhythm of corticosterone secretion

F Spiga, EJ Waite, Y Liu, YM Kershaw… - …, 2011 - academic.oup.com
The activity of the hypothalamic-pituitary-adrenal axis is characterized by an ultradian
pulsatile pattern of glucocorticoid secretion. Despite increasing evidence for the importance …