Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal
homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress …

Metallothioneins (MTs) are small cysteine-rich intracellular proteins with four major isoforms
identified in mammals, designated MT-1 through MT-4. The best known biological functions …

Background/Aims Hepatocellular carcinoma (HCC), accounting for 75-85% of primary liver
cancer cases, is the third leading cause of cancer-related death worldwide. The purpose of …

Overlapping principles of embryonic and tumor biology have been described, with recent
multi-omics campaigns uncovering shared molecular profiles between human pluripotent …

Epigenetic modifications have long been recognized as an essential level in transcriptional
regulation linking behavior and environmental conditions or stimuli with biological …

Abstract Metallothionein-2 (MT-2) was originally discovered as a mediator of zinc
homeostasis and cadmium detoxification. However, MT-2 has recently received increased …

Patients with hepatocellular carcinoma (HCC) bear a heavy burden of disease and
economic burden but have fewer treatment options. Sorafenib, a multi-kinase inhibitor, is the …

Metallothionein is a cysteine-rich protein with a high metal content that is widely found in
nature. In addition to heavy metal detoxification, metallothionein is well known as a potent …

We have previously shown that the holocarboxylase synthetase (HLCS) is overexpressed in
breast cancer tissue of patients, and silencing of its expression in triple-negative cancer cell …

Gliomas are heterogeneous, primary brain tumours that originate from glial cells. The main
type of gliomas is astrocytomas. There are four grades (I-IV) of astrocytoma malignancy …