In spite of significant strides in the treatment of sickle cell disease (SCD), SCD crises are still
responsible for high morbidity and early mortality. While most patients initially seek care in …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

The two most common methods for measuring perfusion with MRI are based on dynamic
susceptibility contrast (DSC) and arterial spin labeling (ASL). Although clinical experience to …

In this study, the static and dynamic characteristics of cerebral blood flow (CBF) in the resting
state were investigated using an arterial spin labeling (ASL) perfusion imaging technique …

Aging is accompanied by a decline of fluid cognitive functions, eg, a slowing of information
processing, working memory, and division of attention. This is at least partly due to structural …

Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia
(SCA), but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and …

Aim Sickle cell disease (SCD) is the commonest cause of childhood stroke worldwide.
Magnetic resonance imaging (MRI) is routinely used to detect additional silent cerebral …

Cerebral vasculopathy is the most severe complication to affect children with sickle cell
anaemia and its pathophysiology is complex. Traditionally, small‐vessel occlusion by …

Objective To provide a comprehensive quantitative review of biological, environmental, and
behavioral correlates across domains of cognitive function in sickle cell disease (SCD) …

Elevation of blood flow velocity in the large cerebral vessels is known to be of substantial
pathophysiologic and prognostic significance in sickle-cell disease (SCD). Its precise cause …